CD132

CD132
已知的結構 PDB 直系同源搜索: PDBe RCSB PDBID列表 2B5I、​2ERJ、​3BPL、​3QAZ、​3QB7、​4GS7
識別號
别名	IL2RG；, CD132, CIDX, IL-2RG, IMD4, P64, SCIDX, SCIDX1, interleukin 2 receptor subunit gamma
外部ID	OMIM：308380 MGI：96551 HomoloGene：172 GeneCards：IL2RG
相關疾病
X性聯嚴重複合免疫缺乏症、​combined immunodeficiency, X-linked
為以下藥物的標靶
denileukin diftitox
基因位置（人类） 染色体 X染色體 基因座 Xq13.1 起始 71,107,404 bp 终止 71,112,108 bp
基因位置（小鼠） 染色体 小鼠X染色体 基因座 X D|X 43.9 cM 起始 100,307,984 bp 终止 100,311,861 bp
RNA表达模式
查阅更多表达数据
基因本體 分子功能 • interleukin-7 receptor activity • interleukin-2 receptor activity • 血浆蛋白结合 • cytokine receptor activity • interleukin-4 receptor activity • interleukin-2 binding • cytokine binding • interleukin-15 receptor activity 細胞組分 • integral component of membrane • 膜 • 细胞膜 • integral component of plasma membrane • external side of plasma membrane • 核内体 • 细胞质基质 • cell surface • receptor complex 生物學過程 • MAPK cascade • 免疫反应 • viral process • 訊息傳遞 • interleukin-2-mediated signaling pathway • interleukin-4-mediated signaling pathway • interleukin-7-mediated signaling pathway • interleukin-15-mediated signaling pathway • interleukin-9-mediated signaling pathway • 分子功能调控 • cytokine-mediated signaling pathway • interleukin-21-mediated signaling pathway • positive regulation of phagocytosis Sources:Amigo / QuickGO
直系同源
物種	人類	小鼠
Entrez	3561	16186
Ensembl	ENSG00000147168	ENSMUSG00000031304
UniProt	P31785	P34902
mRNA​序列	NM_000206	NM_013563 ​NM_001308535
蛋白序列	NP_000197	NP_001295464 ​NP_038591
基因位置​（UCSC）	Chr X: 71.11 – 71.11 Mb	Chr X: 100.31 – 100.31 Mb
PubMed​查找
維基數據
檢視/編輯人類 檢視/編輯小鼠

CD132，又称为共用γ链（Common gamma chain，缩写γ_c)，白介素2受体γ亚基（interleukin-2 receptor subunit gamma，缩写IL-2RG）是一种细胞因子受体亚基，存在于至少六种不同的白介素受体中：包括IL-2、IL-4、IL-7、IL-9、IL-15和IL-21的受体。γ_c是I型细胞因子受体家族中的一种醣蛋白，表达于大部分的淋巴细胞群体，哺乳动物的此基因位于X染色体。

延伸阅读

• Buckley RH. Molecular defects in human severe combined immunodeficiency and approaches to immune reconstitution. Annu Rev Immunol. 2004, 22: 625–55. PMID 15032591. doi:10.1146/annurev.immunol.22.012703.104614. 
• Kalman L, Lindegren ML, Kobrynski L, Vogt R, Hannon H, Howard JT, Buckley R. Mutations in genes required for T-cell development: IL7R, CD45, IL2RG, JAK3, RAG1, RAG2, ARTEMIS, and ADA and severe combined immunodeficiency: HuGE review. Genet Med. 2004, 6 (1): 16–26. PMID 14726805. doi:10.1097/01.GIM.0000105752.80592.A3. 
• Ellery JM, Nicholls PJ. Alternate signalling pathways from the interleukin-2 receptor. Cytokine Growth Factor Rev. 2002, 13 (1): 27–40. PMID 11750878. doi:10.1016/S1359-6101(01)00023-5. 
• Takeshita T, Asao H, Ohtani K, Ishii N, Kumaki S, Tanaka N, Munakata H, Nakamura M, Sugamura K. Cloning of the gamma chain of the human IL-2 receptor. Science. July 1992, 257 (5068): 379–82. PMID 1631559. doi:10.1126/science.1631559. 
• Burton J, Goldman CK, Rao P, Moos M, Waldmann TA. Association of intercellular adhesion molecule 1 with the multichain high-affinity interleukin 2 receptor. Proc. Natl. Acad. Sci. U.S.A. September 1990, 87 (18): 7329–33. PMC 54737 . PMID 1976256. doi:10.1073/pnas.87.18.7329. 
• Oyaizu N, Chirmule N, Kalyanaraman VS, Hall WW, Pahwa R, Shuster M, Pahwa S. Human immunodeficiency virus type 1 envelope glycoprotein gp120 produces immune defects in CD4+ T lymphocytes by inhibiting interleukin 2 mRNA. Proc. Natl. Acad. Sci. U.S.A. March 1990, 87 (6): 2379–83. PMC 53690 . PMID 2315327. doi:10.1073/pnas.87.6.2379. 
• Kornfeld H, Cruikshank WW, Pyle SW, Berman JS, Center DM. Lymphocyte activation by HIV-1 envelope glycoprotein. Nature. September 1988, 335 (6189): 445–8. PMID 2843775. doi:10.1038/335445a0. 
• Bamborough P, Hedgecock CJ, Richards WG. The interleukin-2 and interleukin-4 receptors studied by molecular modelling. Structure. 1995, 2 (9): 839–51. PMID 7529123. doi:10.1016/S0969-2126(94)00085-9. 
• Clark PA, Lester T, Genet S, Jones AM, Hendriks R, Levinsky RJ, Kinnon C. Screening for mutations causing X-linked severe combined immunodeficiency in the IL-2R gamma chain gene by single-strand conformation polymorphism analysis. Hum. Genet. October 1995, 96 (4): 427–32. PMID 7557965. doi:10.1007/BF00191801. 
• Pepper AE, Buckley RH, Small TN, Puck JM. Two mutational hotspots in the interleukin-2 receptor gamma chain gene causing human X-linked severe combined immunodeficiency. Am. J. Hum. Genet. September 1995, 57 (3): 564–71. PMC 1801277 . PMID 7668284. 
• Ohbo K, Takasawa N, Ishii N, Tanaka N, Nakamura M, Sugamura K. Functional analysis of the human interleukin 2 receptor gamma chain gene promoter. J. Biol. Chem. March 1995, 270 (13): 7479–86. PMID 7706294. doi:10.1074/jbc.270.13.7479. 
• Puck JM, Pepper AE, Bédard PM, Laframboise R. Female germ line mosaicism as the origin of a unique IL-2 receptor gamma-chain mutation causing X-linked severe combined immunodeficiency. J. Clin. Invest. February 1995, 95 (2): 895–9. PMC 295580 . PMID 7860773. doi:10.1172/JCI117740. 
• DiSanto JP, Rieux-Laucat F, Dautry-Varsat A, Fischer A, de Saint Basile G. Defective human interleukin 2 receptor gamma chain in an atypical X chromosome-linked severe combined immunodeficiency with peripheral T cells. Proc. Natl. Acad. Sci. U.S.A. September 1994, 91 (20): 9466–70. PMC 44833 . PMID 7937790. doi:10.1073/pnas.91.20.9466. 
• Russell SM, Johnston JA, Noguchi M, Kawamura M, Bacon CM, Friedmann M, Berg M, McVicar DW, Witthuhn BA, Silvennoinen O. Interaction of IL-2R beta and gamma c chains with Jak1 and Jak3: implications for XSCID and XCID. Science. November 1994, 266 (5187): 1042–5. PMID 7973658. doi:10.1126/science.7973658. 
• Ishii N, Asao H, Kimura Y, Takeshita T, Nakamura M, Tsuchiya S, Konno T, Maeda M, Uchiyama T, Sugamura K. Impairment of ligand binding and growth signaling of mutant IL-2 receptor gamma-chains in patients with X-linked severe combined immunodeficiency. J. Immunol. August 1994, 153 (3): 1310–7. PMID 8027558. 
• Johnson K, Choi Y, Wu Z, Ciardelli T, Granzow R, Whalen C, Sana T, Pardee G, Smith K, Creasey A. Soluble IL-2 receptor beta and gamma subunits: ligand binding and cooperativity. Eur. Cytokine Netw. 1994, 5 (1): 23–34. PMID 8049354. 
• Markiewicz S, Subtil A, Dautry-Varsat A, Fischer A, de Saint Basile G. Detection of three nonsense mutations and one missense mutation in the interleukin-2 receptor gamma chain gene in SCIDX1 that differently affect the mRNA processing. Genomics. May 1994, 21 (1): 291–3. PMID 8088810. doi:10.1006/geno.1994.1265. 
• Kondo M, Takeshita T, Ishii N, Nakamura M, Watanabe S, Arai K, Sugamura K. Sharing of the interleukin-2 (IL-2) receptor gamma chain between receptors for IL-2 and IL-4. Science. December 1993, 262 (5141): 1874–7. PMID 8266076. doi:10.1126/science.8266076. 

外部链接

• 醫學主題詞表（MeSH）：Interleukin+Receptor+Common+gamma+Subunit