吲嗪-2-甲酸甲酯

吲嗪-2-甲酸甲酯
识别
CAS号	16959-62-9
性质
化学式	C10H9NO2
摩尔质量	175.18 g·mol−1
	若非注明，所有数据均出自标准状态（25 ℃，100 kPa）下。

吲嗪-2-甲酸甲酯是一种有机化合物，化学式为C₁₀H₉NO₂，它是吲嗪2号位的氢被甲氧羰基取代的产物。它可由β-羟基-α-亚甲基(吡啶-2-基)丙酸甲酯和乙酸酐回流（或和三甲基硅基重氮甲烷在室温反应^[1]）得到。^[2]它在碱中水解，酸化后可以得到吲嗪-2-甲酸。^[3]在碳酸铯和钯催化下，它和3-氟氯苯反应，可以得到3-(3-氟苯基)吲嗪-2-甲酸甲酯。^[4]

参考文献[编辑]

^ Liusheng Zhu, Marc Vimolratana, Sean P. Brown, Julio C. Medina. A mild preparation of substituted indolizines and indole from simple aromatic precursors using (trimethylsilyl)diazomethane. Tetrahedron Letters. 2008-03, 49 (11): 1768–1770 [2022-10-10]. doi:10.1016/j.tetlet.2008.01.067. （原始内容存档于2018-06-17）（英语）.
^ Khethobole C Sekgota, Michelle Isaacs, Heinrich C Hoppe, Ronnett Seldon, Digby F Warner, Setshaba D Khanye, Perry T Kaye. Propylphosphonic acid anhydride–mediated amidation of Morita–Baylis–Hillman–derived indolizine-2-carboxylic acids. Journal of Chemical Research. 2021-07, 45 (7-8): 674–678 [2022-10-10]. ISSN 1747-5198. doi:10.1177/1747519820987156. （原始内容存档于2022-10-17）（英语）.
^ Saraghina M. D. Cunha, Ramon G. de Oliveira, Mário L. A. A. Vasconcellos. Microwave-assisted convenient syntheses of 2-indolizine derivatives from Morita-Baylis-Hillman adducts: new in silico potential ion channel modulators. Journal of the Brazilian Chemical Society. 2013-03, 24 (3): 432–438 [2022-10-10]. ISSN 0103-5053. doi:10.1590/S0103-50532013000300011. （原始内容存档于2018-06-02）（英语）.
^ Bo Liu, Zhi Wang, Ningjie Wu, Mingliang Li, Jingsong You, Jingbo Lan. Discovery of a Full-Color-Tunable Fluorescent Core Framework through Direct CH (Hetero)arylation of N-Heterocycles. Chemistry - A European Journal. 2012-02-06, 18 (6): 1599–1603 [2022-10-10]. doi:10.1002/chem.201103329 （英语）.

[1] Liusheng Zhu, Marc Vimolratana, Sean P. Brown, Julio C. Medina. A mild preparation of substituted indolizines and indole from simple aromatic precursors using (trimethylsilyl)diazomethane. Tetrahedron Letters. 2008-03, 49 (11): 1768–1770 [2022-10-10]. doi:10.1016/j.tetlet.2008.01.067. （原始内容存档于2018-06-17）（英语）.

[2] Khethobole C Sekgota, Michelle Isaacs, Heinrich C Hoppe, Ronnett Seldon, Digby F Warner, Setshaba D Khanye, Perry T Kaye. Propylphosphonic acid anhydride–mediated amidation of Morita–Baylis–Hillman–derived indolizine-2-carboxylic acids. Journal of Chemical Research. 2021-07, 45 (7-8): 674–678 [2022-10-10]. ISSN 1747-5198. doi:10.1177/1747519820987156. （原始内容存档于2022-10-17）（英语）.

[3] Saraghina M. D. Cunha, Ramon G. de Oliveira, Mário L. A. A. Vasconcellos. Microwave-assisted convenient syntheses of 2-indolizine derivatives from Morita-Baylis-Hillman adducts: new in silico potential ion channel modulators. Journal of the Brazilian Chemical Society. 2013-03, 24 (3): 432–438 [2022-10-10]. ISSN 0103-5053. doi:10.1590/S0103-50532013000300011. （原始内容存档于2018-06-02）（英语）.

[4] Bo Liu, Zhi Wang, Ningjie Wu, Mingliang Li, Jingsong You, Jingbo Lan. Discovery of a Full-Color-Tunable Fluorescent Core Framework through Direct CH (Hetero)arylation of N-Heterocycles. Chemistry - A European Journal. 2012-02-06, 18 (6): 1599–1603 [2022-10-10]. doi:10.1002/chem.201103329 （英语）.

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