鳞状细胞癌抗原-2

鳞状细胞癌抗原-2
識別號
别名	SERPINB4；, LEUPIN, PI11, SCCA-2, SCCA1, SCCA2, serpin family B member 4
外部ID	OMIM：600518 MGI：2683293 HomoloGene：76659 GeneCards：SERPINB4
基因位置（人类）
染色体	18號染色體
终止	63,644,256 bp
基因位置（小鼠）
染色体	小鼠1号染色体
终止	107,206,091 bp
基因本體
分子功能	• peptidase inhibitor activity; • 蛋白酶結合; • 酶结合; • serine-type endopeptidase inhibitor activity;
細胞組分	• 細胞質; • 胞內; • 細胞外空間;
生物學過程	• negative regulation of peptidase activity; • regulation of proteolysis; • protection from natural killer cell mediated cytotoxicity; • negative regulation of endopeptidase activity;
	Sources:Amigo / QuickGO
直系同源
	6318
	383548
	ENSG00000206073
	ENSMUSG00000073602
	P48594
	Q9D1Q5
	NM_002974; NM_175041
	NM_198680
	NP_002965; NP_778206
	NP_941373
	維基數據
檢視/編輯人類	檢視/編輯小鼠

鳞状细胞癌抗原-2（英語：Squamous cell carcinoma antigen-2，缩写SCCA-2、SCCA2，也称为丝氨酸蛋白酶抑制剂家族B亚家族成员4，serpin family B member 4，缩写SERPINB4）是一个人类18号染色体上的基因，编码一种丝氨酸蛋白酶抑制剂蛋白，是鳞状细胞癌的肿瘤标志物^[5]^[6]^[7] 。

参考文献[编辑]

^ ^1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000206073 - Ensembl, May 2017
^ ^2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000073602 - Ensembl, May 2017
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Schneider SS, Schick C, Fish KE, Miller E, Pena JC, Treter SD, Hui SM, Silverman GA. A serine proteinase inhibitor locus at 18q21.3 contains a tandem duplication of the human squamous cell carcinoma antigen gene. Proc Natl Acad Sci U S A. May 1995, 92 (8): 3147–51. Bibcode:1995PNAS...92.3147S. PMC 42122 . PMID 7724531. doi:10.1073/pnas.92.8.3147 .
^ Sakata Y, Arima K, Takai T, Sakurai W, Masumoto K, Yuyama N, Suminami Y, Kishi F, Yamashita T, Kato T, Ogawa H, Fujimoto K, Matsuo Y, Sugita Y, Izuhara K. The squamous cell carcinoma antigen 2 inhibits the cysteine proteinase activity of a major mite allergen, Der p 1. J Biol Chem. Feb 2004, 279 (7): 5081–7. PMID 14630915. doi:10.1074/jbc.M311585200 .
^ Entrez Gene: SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4. [2023-04-10]. （原始内容存档于2010-12-05）.