9-甲基鸟嘌呤

9-甲基鸟嘌呤
识别
CAS号	5502-78-3
性质
化学式	C6H7N5O
摩尔质量	165.15 g·mol−1
外观	白色固体
	若非注明，所有数据均出自标准状态（25 ℃，100 kPa）下。

9-甲基鸟嘌呤（9-MeG）是甲基鸟嘌呤的同分异构体之一，化学式为C₆H₇N₅O。它可由N-甲基咪唑-4-酰胺-5-硫脲在氢氧化钠溶液（1 N）中与乙酸铜回流制得。^[1]它和三溴三羰基合铼(I)酸四乙铵在水中于50 °C反应，可以得到[Re(9-MeG-κN⁷)₂(H₂O)(CO)₃]Br·H₂O。^[2]它在乙酸中和溴反应，可以得到8-溴-9-甲基鸟嘌呤。^[3]

参考文献[编辑]

^ ^1.0 ^1.1 Boerge Alhede, Finn Priess Clausen, Joergen Juhl-Christensen, Klaus K. McCluskey, Herbert F. Preikschat. A simple and efficient synthesis of 9-substituted guanines. Cyclodesulfurization of 1-substituted 5-[(thiocarbamoyl)amino]imidazole-4-carboxamides under aqueous basic conditions. The Journal of Organic Chemistry. 1991-03, 56 (6): 2139–2143 [2022-09-01]. ISSN 0022-3263. doi:10.1021/jo00006a033. （原始内容存档于2022-09-01）（英语）.
^ Fabio Zobi, Olivier Blacque, Helmut W. Schmalle, Bernhard Spingler, Roger Alberto. Head-to-Head (HH) and Head-to-Tail (HT) Conformers of cis -Bis Guanine Ligands Bound to the [Re(CO) 3 ] + Core. Inorganic Chemistry. 2004-03-01, 43 (6): 2087–2096 [2022-09-01]. ISSN 0020-1669. doi:10.1021/ic035012a. （原始内容存档于2022-09-01）（英语）.
^ Nelly A. Fosu-Mensah, Wen Jiang, Andrea Brancale, Jun Cai, Andrew D. Westwell. The discovery of purine-based agents targeting triple-negative breast cancer and the αB-crystallin/VEGF protein–protein interaction. Medicinal Chemistry Research. 2019-02, 28 (2): 182–202 [2022-09-01]. ISSN 1054-2523. doi:10.1007/s00044-018-2275-9 （英语）.

[alhede-1] 1.0 ^1.1 Boerge Alhede, Finn Priess Clausen, Joergen Juhl-Christensen, Klaus K. McCluskey, Herbert F. Preikschat. A simple and efficient synthesis of 9-substituted guanines. Cyclodesulfurization of 1-substituted 5-[(thiocarbamoyl)amino]imidazole-4-carboxamides under aqueous basic conditions. The Journal of Organic Chemistry. 1991-03, 56 (6): 2139–2143 [2022-09-01]. ISSN 0022-3263. doi:10.1021/jo00006a033. （原始内容存档于2022-09-01）（英语）.

[2] Fabio Zobi, Olivier Blacque, Helmut W. Schmalle, Bernhard Spingler, Roger Alberto. Head-to-Head (HH) and Head-to-Tail (HT) Conformers of cis -Bis Guanine Ligands Bound to the [Re(CO) 3 ] + Core. Inorganic Chemistry. 2004-03-01, 43 (6): 2087–2096 [2022-09-01]. ISSN 0020-1669. doi:10.1021/ic035012a. （原始内容存档于2022-09-01）（英语）.

[3] Nelly A. Fosu-Mensah, Wen Jiang, Andrea Brancale, Jun Cai, Andrew D. Westwell. The discovery of purine-based agents targeting triple-negative breast cancer and the αB-crystallin/VEGF protein–protein interaction. Medicinal Chemistry Research. 2019-02, 28 (2): 182–202 [2022-09-01]. ISSN 1054-2523. doi:10.1007/s00044-018-2275-9 （英语）.

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