Template:PBB/5728

磷酸酯酶与张力蛋白同源物
	人PTEN的晶体结构图。N-端磷酸酯酶结构域以蓝色表示而C-端C2结构域以红色表示。
有效结构
PDB	直系同源检索：PDBe, RCSB
PDB查询代码列表
	1D5R, 2KYL
标识
代号	PTEN; 10q23del; BZS; CWS1; DEC; GLM2; MHAM; MMAC1; PTEN1; TEP1
扩展标识	遗传学：601728 鼠基因：109583 同源基因：265 GeneCards: PTEN Gene
EC編號	3.1.3.16, 3.1.3.48, 3.1.3.67
基因本体论描述
分子功能	· magnesium ion binding; · phosphatidylinositol-3-phosphatase activity; · phosphoprotein phosphatase activity; · protein serine/threonine phosphatase activity; · protein tyrosine phosphatase activity; · protein binding; · protein tyrosine/serine/threonine phosphatase activity; · lipid binding; · anaphase-promoting complex binding; · phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity; · enzyme binding; · protein kinase binding; · PDZ domain binding; · inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity; · phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity;
细胞成分	· nucleus; · cytoplasm; · cytosol; · plasma membrane; · internal side of plasma membrane; · PML body; · myelin sheath adaxonal region; · cell projection; · neuron projection; · Schmidt-Lanterman incisure;
生物过程	· regulation of cyclin-dependent protein serine/threonine kinase activity; · angiogenesis; · negative regulation of protein phosphorylation; · regulation of B cell apoptotic process; · protein dephosphorylation; · phospholipid metabolic process; · phosphatidylinositol biosynthetic process; · apoptotic process; · induction of apoptosis; · activation of mitotic anaphase-promoting complex activity; · epidermal growth factor receptor signaling pathway; · neuron-neuron synaptic transmission; · synapse assembly; · central nervous system development; · heart development; · learning or memory; · locomotory behavior; · cell proliferation; · positive regulation of cell proliferation; · negative regulation of cell proliferation; · fibroblast growth factor receptor signaling pathway; · regulation of neuron projection development; · negative regulation of phosphatidylinositol 3-kinase cascade; · cell migration; · dentate gyrus development; · central nervous system neuron axonogenesis; · negative regulation of cell migration; · negative regulation of myelination; · regulation of protein stability; · negative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S; · central nervous system myelin maintenance; · regulation of cellular component size; · regulation of myeloid cell apoptotic process; · multicellular organismal response to stress; · social behavior; · peptidyl-tyrosine dephosphorylation; · maternal behavior; · negative regulation of apoptotic process; · protein kinase B signaling cascade; · endothelial cell migration; · inositol phosphate metabolic process; · small molecule metabolic process; · innate immune response; · locomotor rhythm; · negative regulation of cell size; · negative regulation of organ growth; · inositol phosphate dephosphorylation; · phosphatidylinositol dephosphorylation; · neurotrophin TRK receptor signaling pathway; · phosphatidylinositol-mediated signaling; · cardiac muscle tissue development; · forebrain morphogenesis; · brain morphogenesis; · negative regulation of epithelial cell proliferation; · negative regulation of axonogenesis; · protein stabilization; · T cell receptor signaling pathway; · positive regulation of sequence-specific DNA binding transcription factor activity; · negative regulation of focal adhesion assembly; · negative regulation of protein kinase B signaling cascade; · rhythmic synaptic transmission; · canonical Wnt receptor signaling pathway; · synapse maturation; · prepulse inhibition; · male mating behavior; · long-term synaptic potentiation; · prostate gland growth; · dendritic spine morphogenesis; · negative regulation of dendritic spine morphogenesis; · negative regulation of ribosome biogenesis; · negative regulation of cell aging; · negative regulation of excitatory postsynaptic membrane potential; · presynaptic membrane assembly; · postsynaptic density assembly; · positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process; · negative regulation of G1/S transition of mitotic cell cycle; · positive regulation of excitatory postsynaptic membrane potential; · negative regulation of synaptic vesicle clustering;
	Sources: Amigo / QuickGO
直系同源体
	查; 论; 编;

参考资料

^ PDB 1d5r；Lee JO, Yang H, Georgescu MM, Di Cristofano A, Maehama T, Shi Y, Dixon JE, Pandolfi P, Pavletich NP. Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association. Cell. October 1999, 99 (3): 323–34. PMID 10555148. doi:10.1016/S0092-8674(00)81663-3.

[pmid10555148-1] PDB 1d5r；Lee JO, Yang H, Georgescu MM, Di Cristofano A, Maehama T, Shi Y, Dixon JE, Pandolfi P, Pavletich NP. Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association. Cell. October 1999, 99 (3): 323–34. PMID 10555148. doi:10.1016/S0092-8674(00)81663-3.

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