3-氯丙酸
外观
识别信息 | |
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CAS号 | 107-94-8 |
PubChem CID | |
ChemSpider | |
UNII | |
CompTox Dashboard (EPA) | |
ECHA InfoCard | 100.003.214 |
化学信息 | |
化学式 | C3H5ClO2 |
摩尔质量 | 108.52 g·mol−1 |
3D模型(JSmol) | |
熔点 | 42 °C(108 °F) |
沸点 | 204 °C(399 °F) (分解) |
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3-氯丙酸是一种有机化合物,化学式为ClCH2CH2CO2H,它是无色或白色固体,可用作药物或合成中间体,它可由丙烯酸和氯化氢反应制得。[1]
它和三苯基膦在甲苯中回流反应,可以得到三苯基羧乙基氯化𬭸。[2]在三氟甲磺酸的存在下,它和1,3-苯二酚加热反应,可以得到3-氯-1-(2,4-二羟基苯基)-1-丙酮。[3]
参考文献
[编辑]- ^ Samel, Ulf-Rainer; Kohler, Walter; Gamer, Armin Otto; Keuser, Ullrich, Propionic Acid and Derivatives, Ullmann's Encyclopedia of Industrial Chemistry, Weinheim: Wiley-VCH, 2005, doi:10.1002/14356007.a22_223
- ^ Céline Constant-Urban, Mounia Charif, Eric Goffin, Jean-Claude Van Heugen, Benaïssa Elmoualij, Patrice Chiap, Ange Mouithys-Mickalad, Didier Serteyn, Philippe Lebrun, Bernard Pirotte, Pascal De Tullio. Triphenylphosphonium salts of 1,2,4-benzothiadiazine 1,1-dioxides related to diazoxide targeting mitochondrial ATP-sensitive potassium channels. Bioorganic & Medicinal Chemistry Letters. 2013-11, 23 (21): 5878–5881 [2021-10-25]. doi:10.1016/j.bmcl.2013.08.091. (原始内容存档于2018-06-24) (英语).
- ^ Lanying Zhao, Yueshan Li, Yujiao Wang, Zeen Qiao, Zhuang Miao, Jiao Yang, Luyi Huang, Chenyu Tian, Linli Li, Danian Chen, Shengyong Yang. Discovery of 4 H -Chromen-4-one Derivatives as a New Class of Selective Rho Kinase (ROCK) Inhibitors, which Showed Potent Activity in ex Vivo Diabetic Retinopathy Models. Journal of Medicinal Chemistry. 2019-12-12, 62 (23): 10691–10710 [2021-10-25]. ISSN 0022-2623. doi:10.1021/acs.jmedchem.9b01143. (原始内容存档于2021-10-25) (英语).