N-氨甲酰谷氨酸

N-氨甲酰谷氨酸
临床资料
商品名（英语：Drug nomenclature）	Carbaglu, Ucedane
其他名称	(S)-2-ureidopentanedioic acid
AHFS/Drugs.com	Monograph
核准状况	美 DailyMed: acid Carglumic acid;
怀孕分级	澳: B1 ; ;
给药途径	By mouth
ATC码	A16AA05 (WHO) ;
法律规范状态
法律规范	澳：限医生处方（S4）; 加：处方药（℞-only）; 欧：Rx-only; 美：处方药（℞-only）;
药物动力学数据
生物利用度	30%
血浆蛋白结合率	Undetermined
药物代谢	Partial
生物半衰期	4.3 to 9.5 hours
排泄途径	Fecal (60%) and kidney (9%, unchanged)
识别信息
	IUPAC命名法 (2S)-2-(carbamoylamino)pentanedioic acid; ;
CAS号	1188-38-1
PubChem CID	121396;
IUPHAR/BPS	7458;
DrugBank	DB06775 ;
ChemSpider	1265942 ; 108351 ;
UNII	5L0HB4V1EW;
KEGG	D07130 ;
ChEBI	CHEBI:71028 ;
ChEMBL	ChEMBL1201780 ;
CompTox Dashboard（英语：CompTox Chemicals Dashboard） (EPA)	DTXSID7046706 ;
ECHA InfoCard	100.116.323
化学信息
化学式	C6H10N2O5
摩尔质量	190.16 g·mol−1
3D模型（JSmol（英语：JSmol））	交互式图像;
	SMILES C(CC(=O)O)[C@@H](C(=O)O)NC(=O)N;
	InChI InChI=1S/C6H10N2O5/c7-6(13)8-3(5(11)12)1-2-4(9)10/h3H,1-2H2,(H,9,10)(H,11,12)(H3,7,8,13)/t3-/m0/s1 ; Key:LCQLHJZYVOQKHU-VKHMYHEASA-N ;

N-氨甲酰谷氨酸（英语：Carglumic acid，商品名：Carbaglu等）是一种有机化合物，分子式C₆H₁₀N₂O₅，用于治疗高氨血症^[3]^[6]^[7]。

参考文献

^ Prescription medicines: registration of new chemical entities in Australia, 2015. Therapeutic Goods Administration (TGA). 21 June 2022 [10 April 2023].
^ Health Canada New Drug Authorizations: 2015 Highlights. Health Canada. 4 May 2016 [7 April 2024].
^ ^3.0 ^3.1 Carbaglu- carglumic acid tablet. DailyMed. [9 June 2021].
^ Carbaglu EPAR. European Medicines Agency (EMA). 17 September 2018 [9 June 2021].
^ Ucedane EPAR. European Medicines Agency (EMA). 17 September 2018 [9 June 2021].
^ Caldovic L, Morizono H, Daikhin Y, Nissim I, McCarter RJ, Yudkoff M, Tuchman M. Restoration of ureagenesis in N-acetylglutamate synthase deficiency by N-carbamylglutamate. J Pediatr. 2004, 145 (4): 552–4. PMID 15480384. doi:10.1016/j.jpeds.2004.06.047.
^ Elpeleg O, Shaag A, Ben-Shalom E, Schmid T, Bachmann C. N-acetylglutamate synthase deficiency and the treatment of hyperammonemic encephalopathy. Ann Neurol. 2002, 52 (6): 845–9. PMID 12447942. S2CID 24604774. doi:10.1002/ana.10406 .