核苷三磷酸还原酶

核苷三磷酸还原酶; Ribonucleoside-triphosphate reductase
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EC编号	1.17.4.2
CAS号	9068-66-0
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核苷三磷酸还原酶（Ribonucleoside-triphosphate reductase）（EC 1.17.4.2ribonucleotide reductase, 2'-deoxyribonucleoside-triphosphate:oxidized-thioredoxin 2'-oxidoreductase），系统名“2-2'-脱氧核糖核苷三磷酸：硫氧还蛋白二硫键-2'-氧化还原酶”（2'-deoxyribonucleoside-triphosphate:thioredoxin-disulfide 2'-oxidoreductase）^[1]^[2]^[3]，系一种能催化以下化学反应的酶：

2'-脱氧核糖核苷三磷酸+硫氧化还原蛋白二硫键+H₂O $\rightleftharpoons$ 核糖核苷三磷酸+硫氧化还原蛋白

核苷三磷酸还原酶的作用需要cobamide辅酶，同时还要消耗ATP。

参考[编辑]

^ Blakley, R.L. Cobamides and ribonucleotide reduction. I. Cobamide stimulation of ribonucleotide reduction in extracts of Lactobacillus leichmannii. J. Biol. Chem. 1965, 240: 2173–2180. PMID 14299643.
^ Goulian, M. and Beck, W.S. Purification and properties of cobamide-dependent ribonucleotide reductase from Lactobacillus leichmannii. J. Biol. Chem. 1966, 241: 4233–4242. PMID 5924645.
^ Lammers, M. and Follmann, H. The ribonucleotide reductases - a unique group of metalloenzymes essential for cell-proliferation. Struct. Bonding. 1983, 54: 27–91. doi:10.1007/bfb0111318.

外部链接[编辑]

医学主题词表（MeSH）：Ribonucleoside-triphosphate+reductase

[1] Blakley, R.L. Cobamides and ribonucleotide reduction. I. Cobamide stimulation of ribonucleotide reduction in extracts of Lactobacillus leichmannii. J. Biol. Chem. 1965, 240: 2173–2180. PMID 14299643.

[2] Goulian, M. and Beck, W.S. Purification and properties of cobamide-dependent ribonucleotide reductase from Lactobacillus leichmannii. J. Biol. Chem. 1966, 241: 4233–4242. PMID 5924645.

[3] Lammers, M. and Follmann, H. The ribonucleotide reductases - a unique group of metalloenzymes essential for cell-proliferation. Struct. Bonding. 1983, 54: 27–91. doi:10.1007/bfb0111318.

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