CEBPB

CEBPB
已知的结构
PDB	直系同源搜索: PDBe RCSB
PDBID列表
	1GTW、1GU4、1GU5、1H88、1H89、1H8A、1HJB、1IO4、2E42、2E43
识别号
别名	CEBPB；, C/EBP-beta, IL6DBP, NF-IL6, TCF5, CCAAT/enhancer binding protein beta, CCAAT enhancer binding protein beta
外部ID	OMIM：189965 MGI：88373 HomoloGene：3807 GeneCards：CEBPB
基因位置（人类）
染色体	20号染色体
终止	50,192,668 bp
基因位置（小鼠）
染色体	小鼠2号染色体
终止	167,532,338 bp
RNA表达模式
	查阅更多表达数据
基因本体
分子功能	• DNA结合; • sequence-specific DNA binding; • RNA polymerase II transcription regulatory region sequence-specific DNA binding; • protein homodimerization activity; • DNA结合转录因子活性; • DNA-binding transcription activator activity, RNA polymerase II-specific; • 转录因子结合; • histone deacetylase binding; • chromatin binding; • RNA polymerase II cis-regulatory region sequence-specific DNA binding; • 激酶结合; • 血浆蛋白结合; • histone acetyltransferase binding; • ubiquitin-like protein ligase binding; • protein heterodimerization activity; • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding; • RNA polymerase II core promoter sequence-specific DNA binding; • DNA结合转录阻遏物活性，RNA聚合酶II特异性; • DNA-binding transcription factor activity, RNA polymerase II-specific; • glucocorticoid receptor binding;
细胞组分	• 细胞质; • nuclear matrix; • CHOP-C/EBP complex; • 核质; • 细胞核; • condensed chromosome, centromeric region; • RNA polymerase II transcription regulator complex;
生物学过程	• negative regulation of neuron apoptotic process; • mammary gland epithelial cell proliferation; • 细胞分化; • regulation of transcription, DNA-templated; • positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress; • cellular response to organic cyclic compound; • embryonic placenta development; • 记忆; • positive regulation of interleukin-4 production; • response to endoplasmic reticulum stress; • mammary gland epithelial cell differentiation; • transcription, DNA-templated; • positive regulation of transcription, DNA-templated; • negative regulation of T cell proliferation; • liver regeneration; • positive regulation of osteoblast differentiation; • hepatocyte proliferation; • response to lipopolysaccharide; • regulation of osteoclast differentiation; • defense response to bacterium; • 急性期反应; • 免疫反应; • neuron differentiation; • cellular response to interleukin-1; • brown fat cell differentiation; • cellular response to amino acid stimulus; • ovarian follicle development; • liver development; • inflammatory response; • negative regulation of transcription, DNA-templated; • positive regulation of fat cell differentiation; • cellular response to lipopolysaccharide; • fat cell differentiation; • positive regulation of transcription by RNA polymerase II; • intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; • transcription by RNA polymerase II; • granuloma formation; • T-helper 1 cell activation; • negative regulation of transcription by RNA polymerase II; • regulation of odontoblast differentiation; • positive regulation of biomineral tissue development; • positive regulation of sodium-dependent phosphate transport; • positive regulation of inflammatory response; • positive regulation of cold-induced thermogenesis; • regulation of dendritic cell differentiation;
	Sources:Amigo / QuickGO
直系同源
	1051
	12608
	ENSG00000172216
	ENSMUSG00000056501
	P17676
	P28033
	NM_005194; NM_001285878; NM_001285879
	NM_001287738; NM_001287739; NM_009883
	NP_001272807; NP_001272808; NP_005185
	NP_001274667; NP_001274668; NP_034013
	维基数据
查看/编辑人类	查看/编辑小鼠

CCAAT/增强子结合蛋白β，简称C/EBP-β或CEBPB，是一种在人体中由CEBPB基因编码的蛋白质。^[5]^[6]

功能

这种无内含子基因编码的蛋白质是一种bZIP转录因子，可以作为同源二聚体与某些DNA调控区域结合。它还可以与相关蛋白 C/EBP-α、C/EBP-δ和C/EBP-γ形成异二聚体。编码的蛋白质在调节涉及免疫和炎症反应的基因中很重要，并且已显示与IL-6基因中的IL-1反应元件以及几种急性期和细胞因子基因的调节区域结合。此外，编码的蛋白质可以结合启动子和上游元件并刺激I型胶原蛋白基因的表达。^[7]

CEBPB对正常的巨噬细胞功能至关重要，巨噬细胞是一种重要的免疫细胞亚型；无法表达CEBPB的小鼠具有无法分化（特化）的巨噬细胞，因此无法执行其所有生物学功能——包括巨噬细胞介导的肌肉修复。^[8]观察工作表明，血液白细胞中CEBPB的表达与人体肌肉力量呈正相关，^[9]强调了免疫系统，特别是巨噬细胞在维持肌肉功能中的重要性。

CEBPB基因的功能可以通过基于独立验证的siRNA敲低来有效检查。^[10]

靶基因

CEBPB能够增加几个靶基因的表达。其中，一些在神经系统中具有特定作用，如前速激肽原-1基因，产生P物质和神经激肽A^[11]以及负责生物合成重要神经递质乙酰胆碱的胆碱乙酰转移酶。^[12]其他目标包括编码细胞因子的基因，例如IL-6、^[13]IL-4、^[14]IL-5、^[15]和肿瘤坏死因子-α。^[16]还发现编码赋予细胞多药抗性的转运蛋白的基因被CEBPB激活。这样的基因包括ABCC2^[17]和ABCB1。^[18]

相互作用

CEBPB已被证明可以与以下物质相互作用：

参见

Ccaat-enhancer-binding proteins

参考文献

^ ^1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000172216 - Ensembl, May 2017
^ ^2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000056501 - Ensembl, May 2017
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Szpirer C, Riviere M, Cortese R, Nakamura T, Islam MQ, Levan G, Szpirer J. Chromosomal localization in man and rat of the genes encoding the liver-enriched transcription factors C/EBP, DBP, and HNF1/LFB-1 (CEBP, DBP, and transcription factor 1, TCF1, respectively) and of the hepatocyte growth factor/scatter factor gene (HGF). Genomics. Jul 1992, 13 (2): 293–300. PMID 1535333. doi:10.1016/0888-7543(92)90245-N.
^ Cao Z, Umek RM, McKnight SL. Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells. Genes Dev. Oct 1991, 5 (9): 1538–52. PMID 1840554. doi:10.1101/gad.5.9.1538 .
^ Entrez Gene: CEBPB CCAAT/enhancer binding protein (C/EBP), beta.
^ Ruffell D, Mourkioti F, Gambardella A, Kirstetter P, Lopez RG, Rosenthal N, Nerlov C. A CREB-C/EBPbeta cascade induces M2 macrophage-specific gene expression and promotes muscle injury repair. Proc. Natl. Acad. Sci. U.S.A. 2009, 106 (41): 17475–80. Bibcode:2009PNAS..10617475R. PMC 2762675 . PMID 19805133. doi:10.1073/pnas.0908641106 .
^ Harries LW, Pilling LC, Hernandez LD, Bradley-Smith R, Henley W, Singleton AB, Guralnik JM, Bandinelli S, Ferrucci L, Melzer D. CCAAT-enhancer-binding protein-beta expression in vivo is associated with muscle strength. Aging Cell. 2012, 11 (2): 262–8. PMC 3486692 . PMID 22152057. doi:10.1111/j.1474-9726.2011.00782.x.
^ Munkácsy, Gyöngyi; Sztupinszki, Zsófia; Herman, Péter; Bán, Bence; Pénzváltó, Zsófia; Szarvas, Nóra; Győrffy, Balázs. Validation of RNAi Silencing Efficiency Using Gene Array Data shows 18.5% Failure Rate across 429 Independent Experiments. Molecular Therapy: Nucleic Acids. 2016-01-01, 5 (9): e366. ISSN 2162-2531. PMC 5056990 . PMID 27673562. doi:10.1038/mtna.2016.66 （英语）.
^ Kovács KA, Steinmann M, Magistretti PJ, Halfon O, Cardinaux JR. C/EBPbeta couples dopamine signalling to substance P precursor gene expression in striatal neurones. J. Neurochem. September 2006, 98 (5): 1390–9. PMID 16771829. S2CID 36225447. doi:10.1111/j.1471-4159.2006.03957.x.
^ Robert I, Sutter A, Quirin-Stricker C. Synergistic activation of the human choline acetyltransferase gene by c-Myb and C/EBPbeta. Brain Res. Mol. Brain Res. October 2002, 106 (1–2): 124–35. PMID 12393272. doi:10.1016/S0169-328X(02)00419-9.
^ Natsuka S, Akira S, Nishio Y, Hashimoto S, Sugita T, Isshiki H, Kishimoto T. Macrophage differentiation-specific expression of NF-IL6, a transcription factor for interleukin-6. Blood. January 1992, 79 (2): 460–6. PMID 1730090. doi:10.1182/blood.V79.2.460.460 .
^ Davydov IV, Krammer PH, Li-Weber M. Nuclear factor-IL6 activates the human IL-4 promoter in T cells. J. Immunol. December 1995, 155 (11): 5273–9. PMID 7594540.
^ van Dijk TB, Baltus B, Raaijmakers JA, Lammers JW, Koenderman L, de Groot RP. A composite C/EBP binding site is essential for the activity of the promoter of the IL-3/IL-5/granulocyte-macrophage colony-stimulating factor receptor beta c gene. J. Immunol. September 1999, 163 (5): 2674–80. PMID 10453008.
^ Greenwel P, Tanaka S, Penkov D, Zhang W, Olive M, Moll J, Vinson C, Di Liberto M, Ramirez F. Tumor Necrosis Factor Alpha Inhibits Type I Collagen Synthesis through Repressive CCAAT/Enhancer-Binding Proteins. Mol. Cell. Biol. February 2000, 20 (3): 912–8. PMC 85208 . PMID 10629048. doi:10.1128/MCB.20.3.912-918.2000.
^ Tanaka T, Uchiumi T, Hinoshita E, Inokuchi A, Toh S, Wada M, Takano H, Kohno K, Kuwano M. The human multidrug resistance protein 2 gene: functional characterization of the 5'-flanking region and expression in hepatic cells. Hepatology. December 1999, 30 (6): 1507–12. PMID 10573531. S2CID 22514353. doi:10.1002/hep.510300617.
^ Chen GK, Sale S, Tan T, Ermoian RP, Sikic BI. CCAAT/enhancer-binding protein beta (nuclear factor for interleukin 6) transactivates the human MDR1 gene by interaction with an inverted CCAAT box in human cancer cells. Mol. Pharmacol. April 2004, 65 (4): 906–16. PMID 15044620. S2CID 86591291. doi:10.1124/mol.65.4.906.
^ Chen Y, Zhuang S, Cassenaer S, Casteel DE, Gudi T, Boss GR, Pilz RB. Synergism between calcium and cyclic GMP in cyclic AMP response element-dependent transcriptional regulation requires cooperation between CREB and C/EBP-beta. Mol. Cell. Biol. 2003, 23 (12): 4066–82. PMC 156132 . PMID 12773552. doi:10.1128/mcb.23.12.4066-4082.2003.
^ Mo X, Kowenz-Leutz E, Xu H, Leutz A. Ras induces mediator complex exchange on C/EBP beta. Mol. Cell. January 2004, 13 (2): 241–50. PMID 14759369. doi:10.1016/s1097-2765(03)00521-5 .
^ Hattori T, Ohoka N, Hayashi H, Onozaki K. C/EBP homologous protein (CHOP) up-regulates IL-6 transcription by trapping negative regulating NF-IL6 isoform. FEBS Lett. April 2003, 541 (1–3): 33–9. PMID 12706815. S2CID 43792576. doi:10.1016/s0014-5793(03)00283-7 .
^ Fawcett TW, Eastman HB, Martindale JL, Holbrook NJ. Physical and functional association between GADD153 and CCAAT/enhancer-binding protein beta during cellular stress. J. Biol. Chem. June 1996, 271 (24): 14285–9. PMID 8662954. doi:10.1074/jbc.271.24.14285 .
^ Mink S, Haenig B, Klempnauer KH. Interaction and functional collaboration of p300 and C/EBPbeta. Mol. Cell. Biol. November 1997, 17 (11): 6609–17. PMC 232514 . PMID 9343424. doi:10.1128/mcb.17.11.6609.
^ ^24.0 ^24.1 Boruk M, Savory JG, Haché RJ. AF-2-dependent potentiation of CCAAT enhancer binding protein beta-mediated transcriptional activation by glucocorticoid receptor. Mol. Endocrinol. November 1998, 12 (11): 1749–63. PMID 9817600. doi:10.1210/mend.12.11.0191 .
^ Stein B, Yang MX. Repression of the interleukin-6 promoter by estrogen receptor is mediated by NF-kappa B and C/EBP beta. Mol. Cell. Biol. September 1995, 15 (9): 4971–9. PMC 230744 . PMID 7651415. doi:10.1128/mcb.15.9.4971.
^ ^26.0 ^26.1 Foti D, Iuliano R, Chiefari E, Brunetti A. A nucleoprotein complex containing Sp1, C/EBP beta, and HMGI-Y controls human insulin receptor gene transcription. Mol. Cell. Biol. 2003, 23 (8): 2720–32. PMC 152545 . PMID 12665574. doi:10.1128/mcb.23.8.2720-2732.2003.
^ Xie Y, Chen C, Stevenson MA, Auron PE, Calderwood SK. Heat shock factor 1 represses transcription of the IL-1beta gene through physical interaction with the nuclear factor of interleukin 6. J. Biol. Chem. April 2002, 277 (14): 11802–10. PMID 11801594. doi:10.1074/jbc.M109296200 .
^ Miau LH, Chang CJ, Shen BJ, Tsai WH, Lee SC. Identification of heterogeneous nuclear ribonucleoprotein K (hnRNP K) as a repressor of C/EBPbeta-mediated gene activation. J. Biol. Chem. April 1998, 273 (17): 10784–91. PMID 9553145. doi:10.1074/jbc.273.17.10784 .
^ Weber M, Sydlik C, Quirling M, Nothdurfter C, Zwergal A, Heiss P, Bell S, Neumeier D, Ziegler-Heitbrock HW, Brand K. Transcriptional inhibition of interleukin-8 expression in tumor necrosis factor-tolerant cells: evidence for involvement of C/EBP beta. J. Biol. Chem. June 2003, 278 (26): 23586–93. PMID 12707271. doi:10.1074/jbc.M211646200 .
^ Xia C, Cheshire JK, Patel H, Woo P. Cross-talk between transcription factors NF-kappa B and C/EBP in the transcriptional regulation of genes. Int. J. Biochem. Cell Biol. December 1997, 29 (12): 1525–39. PMID 9570146. doi:10.1016/s1357-2725(97)00083-6.
^ Hanlon M, Sealy L. Ras regulates the association of serum response factor and CCAAT/enhancer-binding protein beta. J. Biol. Chem. May 1999, 274 (20): 14224–8. PMID 10318842. doi:10.1074/jbc.274.20.14224 .
^ Sealy L, Malone D, Pawlak M. Regulation of the cfos serum response element by C/EBPbeta. Mol. Cell. Biol. March 1997, 17 (3): 1744–55. PMC 231899 . PMID 9032301. doi:10.1128/mcb.17.3.1744.
^ Kowenz-Leutz E, Leutz A. A C/EBP beta isoform recruits the SWI/SNF complex to activate myeloid genes. Mol. Cell. November 1999, 4 (5): 735–43. PMID 10619021. doi:10.1016/s1097-2765(00)80384-6 .
^ Liu YW, Tseng HP, Chen LC, Chen BK, Chang WC. Functional cooperation of simian virus 40 promoter factor 1 and CCAAT/enhancer-binding protein beta and delta in lipopolysaccharide-induced gene activation of IL-10 in mouse macrophages. J. Immunol. July 2003, 171 (2): 821–8. PMID 12847250. doi:10.4049/jimmunol.171.2.821 .
^ Rooney JW, Calame KL. TIF1beta functions as a coactivator for C/EBPbeta and is required for induced differentiation in the myelomonocytic cell line U937. Genes Dev. 2001, 15 (22): 3023–38. PMC 312827 . PMID 11711437. doi:10.1101/gad.937201.
^ Chang CJ, Chen YL, Lee SC. Coactivator TIF1beta interacts with transcription factor C/EBPbeta and glucocorticoid receptor to induce alpha1-acid glycoprotein gene expression. Mol. Cell. Biol. October 1998, 18 (10): 5880–7. PMC 109174 . PMID 9742105. doi:10.1128/mcb.18.10.5880.
^ Zhang F, Lin M, Abidi P, Thiel G, Liu J. Specific interaction of Egr1 and c/EBPbeta leads to the transcriptional activation of the human low density lipoprotein receptor gene. J. Biol. Chem. November 2003, 278 (45): 44246–54. PMID 12947119. doi:10.1074/jbc.M305564200 .

外部链接

Human CEBPB genome location and CEBPB gene details page in the UCSC Genome Browser（英语：UCSC Genome Browser）.
医学主题词表（MeSH）：CEBPB+protein,+human
FactorBook CEBPB

[refGRCh38Ensembl-1] 1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000172216 - Ensembl, May 2017

[refGRCm38Ensembl-2] 2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000056501 - Ensembl, May 2017

[3] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1535333-5] Szpirer C, Riviere M, Cortese R, Nakamura T, Islam MQ, Levan G, Szpirer J. Chromosomal localization in man and rat of the genes encoding the liver-enriched transcription factors C/EBP, DBP, and HNF1/LFB-1 (CEBP, DBP, and transcription factor 1, TCF1, respectively) and of the hepatocyte growth factor/scatter factor gene (HGF). Genomics. Jul 1992, 13 (2): 293–300. PMID 1535333. doi:10.1016/0888-7543(92)90245-N.

[pmid1840554-6] Cao Z, Umek RM, McKnight SL. Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells. Genes Dev. Oct 1991, 5 (9): 1538–52. PMID 1840554. doi:10.1101/gad.5.9.1538 .

[7] Entrez Gene: CEBPB CCAAT/enhancer binding protein (C/EBP), beta.

[ruffel_mice-8] Ruffell D, Mourkioti F, Gambardella A, Kirstetter P, Lopez RG, Rosenthal N, Nerlov C. A CREB-C/EBPbeta cascade induces M2 macrophage-specific gene expression and promotes muscle injury repair. Proc. Natl. Acad. Sci. U.S.A. 2009, 106 (41): 17475–80. Bibcode:2009PNAS..10617475R. PMC 2762675 . PMID 19805133. doi:10.1073/pnas.0908641106 .

[harries_cebpb-9] Harries LW, Pilling LC, Hernandez LD, Bradley-Smith R, Henley W, Singleton AB, Guralnik JM, Bandinelli S, Ferrucci L, Melzer D. CCAAT-enhancer-binding protein-beta expression in vivo is associated with muscle strength. Aging Cell. 2012, 11 (2): 262–8. PMC 3486692 . PMID 22152057. doi:10.1111/j.1474-9726.2011.00782.x.

[10] Munkácsy, Gyöngyi; Sztupinszki, Zsófia; Herman, Péter; Bán, Bence; Pénzváltó, Zsófia; Szarvas, Nóra; Győrffy, Balázs. Validation of RNAi Silencing Efficiency Using Gene Array Data shows 18.5% Failure Rate across 429 Independent Experiments. Molecular Therapy: Nucleic Acids. 2016-01-01, 5 (9): e366. ISSN 2162-2531. PMC 5056990 . PMID 27673562. doi:10.1038/mtna.2016.66 （英语）.

[pmid16771829-11] Kovács KA, Steinmann M, Magistretti PJ, Halfon O, Cardinaux JR. C/EBPbeta couples dopamine signalling to substance P precursor gene expression in striatal neurones. J. Neurochem. September 2006, 98 (5): 1390–9. PMID 16771829. S2CID 36225447. doi:10.1111/j.1471-4159.2006.03957.x.

[pmid12393272-12] Robert I, Sutter A, Quirin-Stricker C. Synergistic activation of the human choline acetyltransferase gene by c-Myb and C/EBPbeta. Brain Res. Mol. Brain Res. October 2002, 106 (1–2): 124–35. PMID 12393272. doi:10.1016/S0169-328X(02)00419-9.

[pmid1730090-13] Natsuka S, Akira S, Nishio Y, Hashimoto S, Sugita T, Isshiki H, Kishimoto T. Macrophage differentiation-specific expression of NF-IL6, a transcription factor for interleukin-6. Blood. January 1992, 79 (2): 460–6. PMID 1730090. doi:10.1182/blood.V79.2.460.460 .

[pmid7594540-14] Davydov IV, Krammer PH, Li-Weber M. Nuclear factor-IL6 activates the human IL-4 promoter in T cells. J. Immunol. December 1995, 155 (11): 5273–9. PMID 7594540.

[pmid10453008-15] van Dijk TB, Baltus B, Raaijmakers JA, Lammers JW, Koenderman L, de Groot RP. A composite C/EBP binding site is essential for the activity of the promoter of the IL-3/IL-5/granulocyte-macrophage colony-stimulating factor receptor beta c gene. J. Immunol. September 1999, 163 (5): 2674–80. PMID 10453008.

[pmid10629048-16] Greenwel P, Tanaka S, Penkov D, Zhang W, Olive M, Moll J, Vinson C, Di Liberto M, Ramirez F. Tumor Necrosis Factor Alpha Inhibits Type I Collagen Synthesis through Repressive CCAAT/Enhancer-Binding Proteins. Mol. Cell. Biol. February 2000, 20 (3): 912–8. PMC 85208 . PMID 10629048. doi:10.1128/MCB.20.3.912-918.2000.

[pmid10573531-17] Tanaka T, Uchiumi T, Hinoshita E, Inokuchi A, Toh S, Wada M, Takano H, Kohno K, Kuwano M. The human multidrug resistance protein 2 gene: functional characterization of the 5'-flanking region and expression in hepatic cells. Hepatology. December 1999, 30 (6): 1507–12. PMID 10573531. S2CID 22514353. doi:10.1002/hep.510300617.

[pmid15044620-18] Chen GK, Sale S, Tan T, Ermoian RP, Sikic BI. CCAAT/enhancer-binding protein beta (nuclear factor for interleukin 6) transactivates the human MDR1 gene by interaction with an inverted CCAAT box in human cancer cells. Mol. Pharmacol. April 2004, 65 (4): 906–16. PMID 15044620. S2CID 86591291. doi:10.1124/mol.65.4.906.

[pmid12773552-19] Chen Y, Zhuang S, Cassenaer S, Casteel DE, Gudi T, Boss GR, Pilz RB. Synergism between calcium and cyclic GMP in cyclic AMP response element-dependent transcriptional regulation requires cooperation between CREB and C/EBP-beta. Mol. Cell. Biol. 2003, 23 (12): 4066–82. PMC 156132 . PMID 12773552. doi:10.1128/mcb.23.12.4066-4082.2003.

[pmid14759369-20] Mo X, Kowenz-Leutz E, Xu H, Leutz A. Ras induces mediator complex exchange on C/EBP beta. Mol. Cell. January 2004, 13 (2): 241–50. PMID 14759369. doi:10.1016/s1097-2765(03)00521-5 .

[pmid12706815-21] Hattori T, Ohoka N, Hayashi H, Onozaki K. C/EBP homologous protein (CHOP) up-regulates IL-6 transcription by trapping negative regulating NF-IL6 isoform. FEBS Lett. April 2003, 541 (1–3): 33–9. PMID 12706815. S2CID 43792576. doi:10.1016/s0014-5793(03)00283-7 .

[pmid8662954-22] Fawcett TW, Eastman HB, Martindale JL, Holbrook NJ. Physical and functional association between GADD153 and CCAAT/enhancer-binding protein beta during cellular stress. J. Biol. Chem. June 1996, 271 (24): 14285–9. PMID 8662954. doi:10.1074/jbc.271.24.14285 .

[pmid9343424-23] Mink S, Haenig B, Klempnauer KH. Interaction and functional collaboration of p300 and C/EBPbeta. Mol. Cell. Biol. November 1997, 17 (11): 6609–17. PMC 232514 . PMID 9343424. doi:10.1128/mcb.17.11.6609.

[pmid9817600-24] 24.0 ^24.1 Boruk M, Savory JG, Haché RJ. AF-2-dependent potentiation of CCAAT enhancer binding protein beta-mediated transcriptional activation by glucocorticoid receptor. Mol. Endocrinol. November 1998, 12 (11): 1749–63. PMID 9817600. doi:10.1210/mend.12.11.0191 .

[pmid7651415-25] Stein B, Yang MX. Repression of the interleukin-6 promoter by estrogen receptor is mediated by NF-kappa B and C/EBP beta. Mol. Cell. Biol. September 1995, 15 (9): 4971–9. PMC 230744 . PMID 7651415. doi:10.1128/mcb.15.9.4971.

[pmid12665574-26] 26.0 ^26.1 Foti D, Iuliano R, Chiefari E, Brunetti A. A nucleoprotein complex containing Sp1, C/EBP beta, and HMGI-Y controls human insulin receptor gene transcription. Mol. Cell. Biol. 2003, 23 (8): 2720–32. PMC 152545 . PMID 12665574. doi:10.1128/mcb.23.8.2720-2732.2003.

[pmid11801594-27] Xie Y, Chen C, Stevenson MA, Auron PE, Calderwood SK. Heat shock factor 1 represses transcription of the IL-1beta gene through physical interaction with the nuclear factor of interleukin 6. J. Biol. Chem. April 2002, 277 (14): 11802–10. PMID 11801594. doi:10.1074/jbc.M109296200 .

[pmid9553145-28] Miau LH, Chang CJ, Shen BJ, Tsai WH, Lee SC. Identification of heterogeneous nuclear ribonucleoprotein K (hnRNP K) as a repressor of C/EBPbeta-mediated gene activation. J. Biol. Chem. April 1998, 273 (17): 10784–91. PMID 9553145. doi:10.1074/jbc.273.17.10784 .

[pmid12707271-29] Weber M, Sydlik C, Quirling M, Nothdurfter C, Zwergal A, Heiss P, Bell S, Neumeier D, Ziegler-Heitbrock HW, Brand K. Transcriptional inhibition of interleukin-8 expression in tumor necrosis factor-tolerant cells: evidence for involvement of C/EBP beta. J. Biol. Chem. June 2003, 278 (26): 23586–93. PMID 12707271. doi:10.1074/jbc.M211646200 .

[pmid9570146-30] Xia C, Cheshire JK, Patel H, Woo P. Cross-talk between transcription factors NF-kappa B and C/EBP in the transcriptional regulation of genes. Int. J. Biochem. Cell Biol. December 1997, 29 (12): 1525–39. PMID 9570146. doi:10.1016/s1357-2725(97)00083-6.

[pmid10318842-31] Hanlon M, Sealy L. Ras regulates the association of serum response factor and CCAAT/enhancer-binding protein beta. J. Biol. Chem. May 1999, 274 (20): 14224–8. PMID 10318842. doi:10.1074/jbc.274.20.14224 .

[pmid9032301-32] Sealy L, Malone D, Pawlak M. Regulation of the cfos serum response element by C/EBPbeta. Mol. Cell. Biol. March 1997, 17 (3): 1744–55. PMC 231899 . PMID 9032301. doi:10.1128/mcb.17.3.1744.

[pmid10619021-33] Kowenz-Leutz E, Leutz A. A C/EBP beta isoform recruits the SWI/SNF complex to activate myeloid genes. Mol. Cell. November 1999, 4 (5): 735–43. PMID 10619021. doi:10.1016/s1097-2765(00)80384-6 .

[pmid12847250-34] Liu YW, Tseng HP, Chen LC, Chen BK, Chang WC. Functional cooperation of simian virus 40 promoter factor 1 and CCAAT/enhancer-binding protein beta and delta in lipopolysaccharide-induced gene activation of IL-10 in mouse macrophages. J. Immunol. July 2003, 171 (2): 821–8. PMID 12847250. doi:10.4049/jimmunol.171.2.821 .

[pmid11711437-35] Rooney JW, Calame KL. TIF1beta functions as a coactivator for C/EBPbeta and is required for induced differentiation in the myelomonocytic cell line U937. Genes Dev. 2001, 15 (22): 3023–38. PMC 312827 . PMID 11711437. doi:10.1101/gad.937201.

[pmid9742105-36] Chang CJ, Chen YL, Lee SC. Coactivator TIF1beta interacts with transcription factor C/EBPbeta and glucocorticoid receptor to induce alpha1-acid glycoprotein gene expression. Mol. Cell. Biol. October 1998, 18 (10): 5880–7. PMC 109174 . PMID 9742105. doi:10.1128/mcb.18.10.5880.

[pmid12947119-37] Zhang F, Lin M, Abidi P, Thiel G, Liu J. Specific interaction of Egr1 and c/EBPbeta leads to the transcriptional activation of the human low density lipoprotein receptor gene. J. Biol. Chem. November 2003, 278 (45): 44246–54. PMID 12947119. doi:10.1074/jbc.M305564200 .

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]

[12]

[13]

[14]

[15]

[16]

[17]

[18]

[19]

[20]

[21]

[22]

[23]

[24]

[25]

[26]

[27]

[28]

[29]

[30]

[31]

[32]

[33]

[34]

[35]

[36]

[37]