延胡索酰乙酰乙酸
延胡索酰乙酰乙酸 | |
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IUPAC名 (2E)-4,6-Dioxooct-2-enedioic acid | |
別名 | (2E)-4,6-二氧代-2-辛烯二酸 |
識別 | |
CAS號 | 28613-33-4 |
PubChem | 5280398 |
ChemSpider | 4444081 |
SMILES |
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InChI |
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InChIKey | GACSIVHAIFQKTC-OWOJBTEDBU |
MeSH | Fumarylacetoacetate |
性質 | |
化學式 | C8H8O6 |
摩爾質量 | 200.15 g·mol−1 |
若非註明,所有數據均出自標準狀態(25 ℃,100 kPa)下。 |
延胡索酰乙酰乙酸(英語:Fumarylacetoacetic acid或fumarylacetoacetate,也譯為富馬酰乙酰乙酸)是一種酪氨酸降解的代謝中間產物,分子式為C8H8O6,由馬來酰乙酰乙酸異構酶轉化4-馬來酰乙酰乙酸而來[1],再由延胡索醯乙醯乙酸水解酶(FAH)水解為延胡索酸和乙醯乙酸[2][3][4]。
參考文獻[編輯]
- ^ W. E. Knox and M. LeMay-Knox. The oxidation in liver of l-tyrosine to acetoacetate through p-hydroxyphenylpyruvate and homogentisic acid. Biochem. J. 1951, 49 (5): 686–693. PMC 1197578 . PMID 14886367. doi:10.1042/bj0490686.
- ^ Phaneuf, D; Labelle, Y; Bérubé, D; Arden, K; Cavenee, W; Gagné, R; et al. Cloning and expression of the cDNA encoding human fumarylacetoacetate hydrolase, the enzyme deficient in hereditary tyrosinemia: assignment of the gene to chromosome 15. Am J Hum Genet. Apr 1991, 48 (3): 525–35. PMC 1682993 . PMID 1998338. 已忽略未知參數
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(幫助) - ^ Agsteribbe, E; van Faassen, H; Hartog, MV; Reversma, T; Taanman, JW; Pannekoek, H; et al. Nucleotide sequence of cDNA encoding human fumarylacetoacetase. Nucleic Acids Res. Jun 1990, 18 (7): 1887. PMC 330610 . PMID 2336361. doi:10.1093/nar/18.7.1887. 已忽略未知參數
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(幫助) - ^ Entrez Gene: FAH fumarylacetoacetate hydrolase (fumarylacetoacetase). (原始內容存檔於2009-10-18).