Daf-2
| abnormal dauer formation protein 2 | |
|---|---|
| 標識 | |
| 生物 | |
| 符號 | daf-2 |
| Entrez | 175410 |
| RefSeq （mRNA） | NM_065249.5 |
| RefSeq （蛋白質） | NP_497650.4 |
| UniProt | Q968Y9 |
| 其他數據 | |
| 染色體 | III: 2.99 - 3.03 Mb |
DAF-2是秀麗隱桿線蟲（Caenorhabditis elegans）的一個基因，編碼的蛋白與人胰島素樣生長因子1受體（IGF-1R）同源。DAF-2是第一個發現的與老化速率有關的代謝途徑基因[1]。DAF-2也與生殖發育的調控，氧化應激的應對，溫度耐受，缺氧以及對細菌病原體的抵抗有關[2]。辛西婭·凱尼恩（Cynthia Kenyon）獲得的DAF-2突變體線蟲壽命為普通線蟲的兩倍[3]。
參考文獻
[編輯]- ^ Keyton, C. The first long-lived mutants: discovery of the insulin/IGF-1 pathway for ageing.
- ^ Minaxi S Gami and Catherine A Wolkow (2006).
- ^ Jennie B. Dorman, Bella Albinder, Terry Shroyer & Cynthia Kenyon, "The age-1 and daf-2 genes function in a common pathway to control the lifespan of Caenorhabditis elegans," Genetics, volume 141, number 4, pages 1399-1406 (1995); and Javier Apfeld & Cynthia Kenyon, "Cell non-autonomy of C. elegans daf-2 function in the regulation of diapause and lifespan," Cell, v. 95, n.2, pp.199-210 (1998).