酰基輔酶A硫酯酶7

酰基輔酶A硫酯酶7
已知的結構
PDB	直系同源搜尋: PDBe RCSB
PDBID列表
	2QQ2
識別號
別名	ACOT7；, ACH1, ACT, BACH, CTE-II, LACH, LACH1, hBACH, acyl-CoA thioesterase 7
外部ID	OMIM：602587 MGI：1917275 HomoloGene：15780 GeneCards：ACOT7
基因位置（人類）
染色體	1號染色體
終止	6,393,767 bp
基因位置（小鼠）
染色體	小鼠4號染色體
終止	152,356,312 bp
RNA表達模式
	; ;
	查閱更多表達數據
基因本體
分子功能	• palmitoyl-CoA hydrolase activity; • fatty-acyl-CoA binding; • protein homodimerization activity; • carboxylic ester hydrolase activity; • long-chain fatty acyl-CoA binding; • 血漿蛋白結合; • 水解酶活性; • acyl-CoA hydrolase activity; • myristoyl-CoA hydrolase activity; • thiolester hydrolase activity;
細胞組分	• 細胞質基質; • 核質; • 線粒體; • 外排體; • 細胞質;
生物學過程	• medium-chain fatty acid biosynthetic process; • medium-chain fatty-acyl-CoA catabolic process; • long-chain fatty-acyl-CoA catabolic process; • coenzyme A biosynthetic process; • palmitic acid biosynthetic process; • acyl-CoA metabolic process; • 脂質代謝; • 脂肪酸代謝;
	Sources:Amigo / QuickGO
直系同源
	11332
	70025
	ENSG00000097021
	ENSMUSG00000028937
	O00154
	Q91V12
NM_181866; NM_007274; NM_181862; NM_181863; NM_181864;
	NM_181865
NM_001146057; NM_001146058; NM_133348; NM_001369273; NM_001369274;
	NM_001369275; NM_001369276
	NP_009205; NP_863654; NP_863655; NP_863656
NP_001139529; NP_001139530; NP_579926; NP_001356202; NP_001356203;
	NP_001356204; NP_001356205
	維基數據
檢視/編輯人類	檢視/編輯小鼠

酰基輔酶A硫酯酶7（英語：Acyl-CoA thioesterase 7）是一種在人類中由ACOT7基因編碼的酶。^[5]^[6]^[7]^[8]

該基因編碼酰基輔酶家族的一個成員。編碼的蛋白質水解棕櫚酰輔酶A的輔酶A 硫酯和其他長鏈脂肪酸。該基因表達的減少可能與內側顳葉癲癇有關。編碼具有不同亞細胞位置的不同異構體的選擇性剪接轉錄變體已經被表徵。^[8]

參考資料[編輯]

^ ^1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000097021 - Ensembl, May 2017
^ ^2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000028937 - Ensembl, May 2017
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Yamada J, Kurata A, Hirata M, Taniguchi T, Takama H, Furihata T, Shiratori K, Iida N, Takagi-Sakuma M, Watanabe T, Kurosaki K, Endo T, Suga T. Purification, molecular cloning, and genomic organization of human brain long-chain acyl-CoA hydrolase. J Biochem. Mar 2000, 126 (6): 1013–9. PMID 10578051. doi:10.1093/oxfordjournals.jbchem.a022544.
^ Hunt MC, Yamada J, Maltais LJ, Wright MW, Podesta EJ, Alexson SE. A revised nomenclature for mammalian acyl-CoA thioesterases/hydrolases. J Lipid Res. Aug 2005, 46 (9): 2029–32. PMID 16103133. doi:10.1194/jlr.E500003-JLR200 .
^ Hunt MC, Rautanen A, Westin MA, Svensson LT, Alexson SE. Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs. FASEB J. Aug 2006, 20 (11): 1855–64 [2023-03-07]. PMID 16940157. S2CID 501610. doi:10.1096/fj.06-6042com. （原始內容存檔於2017-11-03）.
^ ^8.0 ^8.1 Entrez Gene: ACOT7 acyl-CoA thioesterase 7.

外部連結[編輯]

Human ACOT7 genome location and ACOT7 gene details page in the UCSC Genome Browser（英語：UCSC Genome Browser）.

延申閱讀[編輯]

Yamada J. Long-chain acyl-CoA hydrolase in the brain.. Amino Acids. 2006, 28 (3): 273–8. PMID 15731883. S2CID 10678899. doi:10.1007/s00726-005-0181-1.
Yamada J, Kuramochi Y, Takagi M, et al. Human brain acyl-CoA hydrolase isoforms encoded by a single gene.. Biochem. Biophys. Res. Commun. 2003, 299 (1): 49–56. PMID 12435388. doi:10.1016/S0006-291X(02)02587-1.
Strausberg RL, Feingold EA, Grouse LH, et al. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc. Natl. Acad. Sci. U.S.A. 2003, 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899 .
Ota T, Suzuki Y, Nishikawa T, et al. Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. 2004, 36 (1): 40–5. PMID 14702039. doi:10.1038/ng1285 .
Gerhard DS, Wagner L, Feingold EA, et al. The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC). Genome Res. 2004, 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
Yang JW, Czech T, Yamada J, et al. Aberrant cytosolic acyl-CoA thioester hydrolase in hippocampus of patients with mesial temporal lobe epilepsy. Amino Acids. 2005, 27 (3–4): 269–75. PMID 15592755. S2CID 2832201. doi:10.1007/s00726-004-0138-9.
Gregory SG, Barlow KF, McLay KE, et al. The DNA sequence and biological annotation of human chromosome 1. Nature. 2006, 441 (7091): 315–21. Bibcode:2006Natur.441..315G. PMID 16710414. doi:10.1038/nature04727 .
Lim J, Hao T, Shaw C, et al. A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. Cell. 2006, 125 (4): 801–14. PMID 16713569. S2CID 13709685. doi:10.1016/j.cell.2006.03.032 .

[refGRCh38Ensembl-1] 1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000097021 - Ensembl, May 2017

[refGRCm38Ensembl-2] 2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000028937 - Ensembl, May 2017

[3] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10578051-5] Yamada J, Kurata A, Hirata M, Taniguchi T, Takama H, Furihata T, Shiratori K, Iida N, Takagi-Sakuma M, Watanabe T, Kurosaki K, Endo T, Suga T. Purification, molecular cloning, and genomic organization of human brain long-chain acyl-CoA hydrolase. J Biochem. Mar 2000, 126 (6): 1013–9. PMID 10578051. doi:10.1093/oxfordjournals.jbchem.a022544.

[pmid16103133-6] Hunt MC, Yamada J, Maltais LJ, Wright MW, Podesta EJ, Alexson SE. A revised nomenclature for mammalian acyl-CoA thioesterases/hydrolases. J Lipid Res. Aug 2005, 46 (9): 2029–32. PMID 16103133. doi:10.1194/jlr.E500003-JLR200 .

[pmid16940157-7] Hunt MC, Rautanen A, Westin MA, Svensson LT, Alexson SE. Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs. FASEB J. Aug 2006, 20 (11): 1855–64 [2023-03-07]. PMID 16940157. S2CID 501610. doi:10.1096/fj.06-6042com. （原始內容存檔於2017-11-03）.

[entrez-8] 8.0 ^8.1 Entrez Gene: ACOT7 acyl-CoA thioesterase 7.

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