多巴胺转运体

多巴胺转运体
识别号
别名	SLC6A3；, solute carrier family 6 (neurotransmitter transporter), member 3, DAT, DAT1, PKDYS, solute carrier family 6 member 3, Dopamine transporter, PKDYS1
外部ID	OMIM：126455 MGI：94862 HomoloGene：55547 GeneCards：SLC6A3
相关疾病
	infantile parkinsonism-dystonia、物质使用疾患
为以下药物的标靶
	阿托莫西汀、丁氨苯丙酮、氯米帕明、去甲文拉法辛、右旋安非他命、右旋哌甲酯、gbr-12935、左旋米那普伦、马吲哚、哌甲酯、(RS)-nomifensine、苯乙肼、西布曲明、曲米帕明、WIN35428、serdexmethylphenidate chloride、右旋哌甲酯、右旋安非他命、苯丙胺、liafensine、甲基苯丙胺、安非拉酮、马吲哚、methylphenidate hydrochloride、dasotraline、diethylpropion hydrochloride、phenmetrazine hydrochloride
基因位置（人类）
染色体	5号染色体
终止	1,445,440 bp
基因位置（小鼠）
染色体	小鼠13号染色体
终止	73,726,791 bp
RNA表达模式
	查阅更多表达数据
基因本体
分子功能	• protein N-terminus binding; • dopamine:sodium symporter activity; • 金属离子结合; • neurotransmitter:sodium symporter activity; • dopamine binding; • 血浆蛋白结合; • symporter activity; • monoamine transmembrane transporter activity; • 大分子复合物结合; • 蛋白酶结合; • signaling receptor binding; • protein phosphatase 2A binding;
细胞组分	• 细胞质; • integral component of membrane; • 膜; • 细胞膜; • integral component of plasma membrane; • cell surface; • 轴突; • flotillin complex; • neuronal cell body; • 脂筏模型; • presynapse; • neuron projection; • dopaminergic synapse; • integral component of postsynaptic membrane; • integral component of presynaptic membrane;
生物学过程	• response to cocaine; • 前脉冲抑制; • response to organic cyclic compound; • locomotory behavior; • dopamine biosynthetic process; • response to nicotine; • 老化; • neurotransmitter biosynthetic process; • monoamine transport; • adenohypophysis development; • regulation of dopamine metabolic process; • response to iron ion; • sensory perception of smell; • dopamine uptake involved in synaptic transmission; • dopamine catabolic process; • dopamine transport; • positive regulation of multicellular organism growth; • response to cAMP; • 哺乳; • response to ethanol; • neurotransmitter transport; • dopamine uptake; • transmembrane transport; • neurotransmitter uptake;
	Sources:Amigo / QuickGO
直系同源
	6531
	13162
	ENSG00000142319; ENSG00000276996
	ENSMUSG00000021609
	Q01959
	Q61327
	NM_001044
	NM_010020
	NP_001035
	NP_034150
	维基数据
查看/编辑人类	查看/编辑小鼠

多巴胺转运体（英语：Dopamine transporter，DAT；溶质载体家族6成员3（英语：solute carrier family 6 member 3，SLC6A3））是负责将神经递质从突触间隙运输回细胞质底物的跨膜蛋白。由多巴胺转运体进行的再摄取是将多巴胺从突触间隙清除的主要机制，除了前额叶，在前额叶多巴胺由去甲肾上腺素转运体回收^[7]。

DAT与一些多巴胺相关的疾病有关, 包含注意力不足过动症、躁郁症、重性抑郁障碍、酗酒。编码 DAT 蛋白的基因位于人类第5号染色体，含有15个外显子，共64kbp长。

功能[编辑]

DAT从突触间隙（英语：synaptic cleft）移除多巴胺，运回细胞内而终止神经递质的信号。它属于一种integral membrane protein（英语：integral membrane protein）^[8]。

参见[编辑]

单胺转运体（英语：Monoamine transporter）
去甲肾上腺素转运体
血清素转运体
Glutamate transporter（英语：Glutamate transporter）

参考资料[编辑]

^ 與多巴胺轉運體相關的疾病；在維基數據上查看/編輯參考.
^ 對多巴胺轉運體起作用的藥物；在維基數據上查看/編輯參考.
^ ^3.0 ^3.1 ^3.2 GRCh38: Ensembl release 89: ENSG00000142319、ENSG00000276996 - Ensembl, May 2017
^ ^4.0 ^4.1 ^4.2 GRCm38: Ensembl release 89: ENSMUSG00000021609 - Ensembl, May 2017
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Carboni E, Tanda GL, Frau R, Di Chiara G. Blockade of the noradrenaline carrier increases extracellular dopamine concentrations in the prefrontal cortex: evidence that dopamine is taken up in vivo by noradrenergic terminals. J. Neurochem. 1990, 55 (3): 1067–70. PMID 2117046. doi:10.1111/j.1471-4159.1990.tb04599.x.
^ Schultz W. Predictive reward signal of dopamine neurons. J. Neurophysiol. 1998, 80 (1): 1–27. PMID 9658025.

外部链接[编辑]

[1] 與多巴胺轉運體相關的疾病；在維基數據上查看/編輯參考.

[2] 對多巴胺轉運體起作用的藥物；在維基數據上查看/編輯參考.

[refGRCh38Ensembl-3] 3.0 ^3.1 ^3.2 GRCh38: Ensembl release 89: ENSG00000142319、ENSG00000276996 - Ensembl, May 2017

[refGRCm38Ensembl-4] 4.0 ^4.1 ^4.2 GRCm38: Ensembl release 89: ENSMUSG00000021609 - Ensembl, May 2017

[5] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[6] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2117046-7] Carboni E, Tanda GL, Frau R, Di Chiara G. Blockade of the noradrenaline carrier increases extracellular dopamine concentrations in the prefrontal cortex: evidence that dopamine is taken up in vivo by noradrenergic terminals. J. Neurochem. 1990, 55 (3): 1067–70. PMID 2117046. doi:10.1111/j.1471-4159.1990.tb04599.x.

[Schultz-8] Schultz W. Predictive reward signal of dopamine neurons. J. Neurophysiol. 1998, 80 (1): 1–27. PMID 9658025.

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