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组氨酸脱羧酶

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组氨酸脱羧酶
在组氨酸脱羧酶作用下从组氨酸到组织胺的转化
识别码
EC编号 4.1.1.22
CAS号 9024-61-7
数据库
IntEnz IntEnz浏览
BRENDA（英语：BRENDA） BRENDA入口
ExPASy（英语：ExPASy） NiceZyme浏览
KEGG KEGG入口
MetaCyc（英语：MetaCyc） 代谢路径
PRIAM（英语：PRIAM_enzyme-specific_profiles） 概述
PDB RCSB PDB PDBj PDBe PDBsum
基因本体 AmiGO / EGO
组氨酸脱羧酶
标识
代号 HDC; MGC163399
扩展标识 遗传学：142704 鼠基因：96062 同源基因：20490 GeneCards: HDC Gene
EC编号 4.1.1.22
直系同源体
物种 人类 小鼠
Entrez 3067 15186
Ensembl ENSG00000140287 ENSMUSG00000027360
UniProt P19113 P23738
mRNA序列 NM_002112 NM_008230
蛋白序列 NP_002103 NP_032256
基因位置 Chr 15:
48.32 – 48.35 Mb		 Chr 2:
126.42 – 126.44 Mb
PubMed查询 [1] [2]

组氨酸脱羧酶（英语：Histidine decarboxylase，HDC）是一种以如下方式在维生素B6的帮助下催化从组氨酸生成组织胺的反应的酶：[1][2][3]

C6H9N3O2 → C5H9N3 + CO2

组氨酸脱羧酶能转变组氨酸到组织胺。

在人体中，组氨酸脱羧酶由HDC基因编码。[4][5]

生物胺组织胺在许多生理过程中有重要的调节作用，包括神经传递、胃酸分泌、平滑肌舒张。从组氨酸到组织胺的生物合成由L-组氨酸脱羧酶催化。这个同源二聚体酶是一个依赖磷酸吡哆醛（PLP）的脱羧酶，并对其底物组氨酸有高度特异性。[4]

参考

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  1. ^ Epps HM. Studies on bacterial amino-acid decarboxylases: 4. l(-)-histidine decarboxylase from Cl. welchii Type A. Biochem. J. 1945, 39 (1): 42–6. PMC 1258146 可免费查阅. PMID 16747851. 
  2. ^ Riley WD, Snell EE. Histidine decarboxylase of Lactobacillus 30a. IV. The presence of covalently bound pyruvate as the prosthetic group. Biochemistry. October 1968, 7 (10): 3520–8. PMID 5681461. 
  3. ^ Rosenthaler J, Guirard BM, Chang GW, Snell EE. Purification and properties of histidine decarboxylase from Lactobacillus 30a. Proc. Natl. Acad. Sci. U.S.A. July 1965, 54 (1): 152–8. PMC 285813 可免费查阅. PMID 5216347. 
  4. ^ 4.0 4.1 Entrez Gene: histidine decarboxylase. （原始内容存档于2020-03-28）. 
  5. ^ Bruneau G, Nguyen VC, Gros F, Bernheim A, Thibault J. Preparation of a rat brain histidine decarboxylase (HDC) cDNA probe by PCR and assignment of the human HDC gene to chromosome 15. Hum. Genet. November 1992, 90 (3): 235–8. PMID 1487235. 

扩展阅读

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  • Need AC, Keefe RS, Ge D; et al. Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis.. Eur. J. Hum. Genet. 2009, 17 (7): 946–57. PMID 19156168. doi:10.1038/ejhg.2008.264. 
  • Masini E, Fabbroni V, Giannini L; et al. Histamine and histidine decarboxylase up-regulation in colorectal cancer: correlation with tumor stage.. Inflamm. Res. 2005,. 54 Suppl 1: S80–1. PMID 15928846. doi:10.1007/s00011-004-0437-3. 
  • Li Z, Liu J, Tang F; et al. Expression of non-mast cell histidine decarboxylase in tumor-associated microvessels in human esophageal squamous cell carcinomas.. APMIS. 2008, 116 (12): 1034–42. PMID 19133005. doi:10.1111/j.1600-0463.2008.01048.x. 
  • Szafranski K, Schindler S, Taudien S; et al. Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns.. Genome Biol. 2007, 8 (8): R154. PMID 17672918. doi:10.1186/gb-2007-8-8-r154. 
  • Ai W, Liu Y, Langlois M, Wang TC. Kruppel-like factor 4 (KLF4) represses histidine decarboxylase gene expression through an upstream Sp1 site and downstream gastrin responsive elements.. J. Biol. Chem. 2004, 279 (10): 8684–93. PMID 14670968. doi:10.1074/jbc.M308278200. 
  • Raychowdhury R, Fleming JV, McLaughlin JT; et al. Identification and characterization of a third gastrin response element (GAS-RE3) in the human histidine decarboxylase gene promoter.. Biochem. Biophys. Res. Commun. 2002, 297 (5): 1089–95. PMID 12372397. 
  • Kimura K, Wakamatsu A, Suzuki Y; et al. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.. Genome Res. 2006, 16 (1): 55–65. PMID 16344560. doi:10.1101/gr.4039406. 
  • Sköldberg F, Portela-Gomes GM, Grimelius L; et al. Histidine decarboxylase, a pyridoxal phosphate-dependent enzyme, is an autoantigen of gastric enterochromaffin-like cells.. J. Clin. Endocrinol. Metab. 2003, 88 (4): 1445–52. PMID 12679420. 
  • Brew O, Lakasing L, Sullivan M. Differential activity of histidine decarboxylase in normal and pre-eclamptic placentae.. Placenta: 585–7. PMID 16822545. doi:10.1016/j.placenta.2006.05.003. 
  • Zhang F, Xiong DH, Wang W; et al. HDC gene polymorphisms are associated with age at natural menopause in Caucasian women.. Biochem. Biophys. Res. Commun. 2006, 348 (4): 1378–82. PMID 16919600. doi:10.1016/j.bbrc.2006.08.008. 
  • Tippens AS, Gruetter CA. Detection of histidine decarboxylase mRNA in human vascular smooth muscle and endothelial cells.. Inflamm. Res. 2004, 53 (6): 215–6. PMID 15167966. doi:10.1007/s00011-004-1252-6. 
  • Siezen CL, Bont L, Hodemaekers HM; et al. Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes.. Pediatr. Infect. Dis. J. 2009, 28 (4): 333–5. PMID 19258923. doi:10.1097/INF.0b013e31818e2aa9. 
  • Morgan TK, Montgomery K, Mason V; et al. Upregulation of histidine decarboxylase expression in superficial cortical nephrons during pregnancy in mice and women.. Kidney Int. 2006, 70 (2): 306–14. PMID 16760908. doi:10.1038/sj.ki.5001553. 
  • Papadopoulou N, Kalogeromitros D, Staurianeas NG; et al. Corticotropin-releasing hormone receptor-1 and histidine decarboxylase expression in chronic urticaria.. J. Invest. Dermatol. 2005, 125 (5): 952–5. PMID 16297195. doi:10.1111/j.0022-202X.2005.23913.x. 
  • Janssen R, Bont L, Siezen CL; et al. Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes.. J. Infect. Dis. 2007, 196 (6): 826–34. PMID 17703412. doi:10.1086/520886. 
  • Strausberg RL, Feingold EA, Grouse LH; et al. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.. Proc. Natl. Acad. Sci. U.S.A. 2002, 99 (26): 16899–903. PMID 12477932. doi:10.1073/pnas.242603899. 
  • Aichberger KJ, Mayerhofer M, Vales A; et al. The CML-related oncoprotein BCR/ABL induces expression of histidine decarboxylase (HDC) and the synthesis of histamine in leukemic cells.. Blood. 2006, 108 (10): 3538–47. PMID 16849647. doi:10.1182/blood-2005-12-028456. 
  • Lee JK, Kim HT, Cho SM; et al. Characterization of 458 single nucleotide polymorphisms of disease candidate genes in the Korean population.. J. Hum. Genet. 2003, 48 (5): 213–6. PMID 12768436. doi:10.1007/s10038-003-0011-9. 
  • Jeong HJ, Moon PD, Kim SJ; et al. Activation of hypoxia-inducible factor-1 regulates human histidine decarboxylase expression.. Cell. Mol. Life Sci. 2009, 66 (7): 1309–19. PMID 19266161. doi:10.1007/s00018-009-9001-1. 

外部链接

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