JWH-073

JWH-073
法律規範狀態
法律規範	加：Schedule II; 德：Anlage II; 英：Class B; 美：附表I; Illegal in Latvia & Poland;
识别信息
	IUPAC命名法 Naphthalen-1-yl-(1-butylindol-3-yl)methanone; ;
CAS号	208987-48-8
PubChem CID	10471670;
ChemSpider	8647081 ;
UNII	BBX3BP2772;
KEGG	C22764;
CompTox Dashboard（英语：CompTox Chemicals Dashboard） (EPA)	DTXSID20175042 ;
ECHA InfoCard	100.230.192
化学信息
化学式	C23H21NO
摩尔质量	327.43 g·mol−1
3D模型（JSmol（英语：JSmol））	交互式图像;
	SMILES CCCCN1C=C(C2=CC=CC=C21)C(=O)C3=CC=CC4=CC=CC=C43;
	InChI InChI=1S/C23H21NO/c1-2-3-15-24-16-21(19-12-6-7-14-22(19)24)23(25)20-13-8-10-17-9-4-5-11-18(17)20/h4-14,16H,2-3,15H2,1H3 ; Key:VCHHHSMPMLNVGS-UHFFFAOYSA-N ;

JWH-073，化学名N-正丁基-3-(1-萘甲酰基)吲哚，分子式C₂₃H₂₁NO，属于萘甲酰基吲哚类JWH系列大麻素，是大麻素受体CB₁和CB₂的全激动剂^[3]，由约翰·威廉·霍夫曼小组合成^[4]。

参考文献

^ Grozījumi Ministru kabineta 2005.gada 8.novembra noteikumos Nr.847 "Noteikumi par Latvijā kontrolējamajām narkotiskajām vielām, psihotropajām vielām un prekursoriem". Legal Acts of the Republic of Latvia. [2024-01-29]. （原始内容存档于2010-09-14）（Latvian）.
^ Anvisa. RDC Nº 804 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial [Collegiate Board Resolution No. 804 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control]. Diário Oficial da União. 2023-07-24 (2023-07-25) [2023-08-27]. （原始内容存档于2023-08-27）（巴西葡萄牙语）.
^ Lisa K. Brents, Anna Gallus-Zawada, Anna Radominska-Pandya, Tamara Vasiljevik, Thomas E Prisinzano, William E Fantegrossi, Jeffery H Moran, Paul L Prather. Monohydroxylated metabolites of the K2 synthetic cannabinoid JWH-073 retain intermediate to high cannabinoid 1 receptor (CB1R) affinity and exhibit neutral antagonist to partial agonist activity. Biochemical Pharmacology. 2012, 83 (7): 952–961 [2024-01-29]. PMID 22266354. doi:10.1016/j.bcp.2012.01.004. hdl:1808/22684 . （原始内容存档于2023-10-31）. JWH-073 displays equivalent efficacy to that of the CB1R full agonist CP-55,940
^ Aung MM, Griffin G, Huffman JW, Wu M, Keel C, Yang B, Showalter VM, Abood ME, Martin BR. Influence of the N-1 alkyl chain length of cannabimimetic indoles upon CB₁ and CB₂)receptor binding. Drug Alcohol Depend. August 2000, 60 (2): 133–40. PMID 10940540. doi:10.1016/S0376-8716(99)00152-0.

外部链接

[1] Grozījumi Ministru kabineta 2005.gada 8.novembra noteikumos Nr.847 "Noteikumi par Latvijā kontrolējamajām narkotiskajām vielām, psihotropajām vielām un prekursoriem". Legal Acts of the Republic of Latvia. [2024-01-29]. （原始内容存档于2010-09-14）（Latvian）.

[2] Anvisa. RDC Nº 804 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial [Collegiate Board Resolution No. 804 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control]. Diário Oficial da União. 2023-07-24 (2023-07-25) [2023-08-27]. （原始内容存档于2023-08-27）（巴西葡萄牙语）.

[pmid22266354-3] Lisa K. Brents, Anna Gallus-Zawada, Anna Radominska-Pandya, Tamara Vasiljevik, Thomas E Prisinzano, William E Fantegrossi, Jeffery H Moran, Paul L Prather. Monohydroxylated metabolites of the K2 synthetic cannabinoid JWH-073 retain intermediate to high cannabinoid 1 receptor (CB1R) affinity and exhibit neutral antagonist to partial agonist activity. Biochemical Pharmacology. 2012, 83 (7): 952–961 [2024-01-29]. PMID 22266354. doi:10.1016/j.bcp.2012.01.004. hdl:1808/22684 . （原始内容存档于2023-10-31）. JWH-073 displays equivalent efficacy to that of the CB1R full agonist CP-55,940

[pmid10940540-4] Aung MM, Griffin G, Huffman JW, Wu M, Keel C, Yang B, Showalter VM, Abood ME, Martin BR. Influence of the N-1 alkyl chain length of cannabimimetic indoles upon CB₁ and CB₂)receptor binding. Drug Alcohol Depend. August 2000, 60 (2): 133–40. PMID 10940540. doi:10.1016/S0376-8716(99)00152-0.

[1]

[3]

[4]