癸酰氯

癸酰氯
识别
CAS号	112-13-0
SMILES	CCCCCCCCCC(=O)Cl;
性质
化学式	C10H19ClO
摩尔质量	190.71 g·mol−1
密度	0.943±0.06 g·cm−3（20 °C）
熔点	−34.5 °C（238.7 K）
沸点	115—116 °C（388—389 K）（5 torr）; 116 °C（389 K）（18 torr）
	若非注明，所有数据均出自标准状态（25 ℃，100 kPa）下。

癸酰氯是一种有机化合物，化学式为C₁₀H₁₉ClO。它可由1-癸酸和氯化亚砜（或草酰氯^[5]）回流反应制得。^[6]它可以被Zn(BH₄)₂–TMEDA在乙醚中还原为1-癸醇。^[7]在吡啶的存在下，它和苯胺在二氯甲烷中反应，可以得到N-苯基癸酰胺。^[8]

参考文献

^ Calculated using Advanced Chemistry Development (ACD/Labs) Software V11.02 ((C) 1994-2021 ACD/Labs). Retrieved from SciFinderⁿ. [2021-01-26].
^ "PhysProp" data were obtained from Syracuse Research Corporation of Syracuse, New York (US). Retrieved from SciFinderⁿ. [2021-01-26].
^ Toriyama, Masaharu; Kamijo, Haruo; Motohashi, Shigeyasu; Takido, Toshio; Itabashi, Kunio. A Facile Synthesis of Thioacids by Hydrolysis of 1-(Acylthio)ethaniminium Chlorides. Phosphorus, Sulfur, and Silicon and the Related Elements. 2010, 178 (8): 1661–1665. ISSN 1042-6507. doi:10.1080/10426500307837.
^ Cainelli, Gianfranco; Contento, Michele; Manescalchi, Francesco; Plessi, Laura. Polymer-Bonded Lewis Acids in Organic Synthesis: Conversion of Carboxylic Acids into Acyl Chlorides and of Alcohols into Alkyl Chlorides or Bromides by Polymer-Bonded Phosphorus Reagents. Synthesis. 1983, 1983 (04): 306–308. ISSN 0039-7881. doi:10.1055/s-1983-30314.
^ Srikanth Vudhgiri, Dhevendar Koude, Dileep Kumar Veeragoni, Sunil Misra, R.B.N. Prasad, Ram Chandra Reddy Jala. Synthesis and biological evaluation of 5-fatty-acylamido-1, 3, 4-thiadiazole-2-thioglycosides. Bioorganic & Medicinal Chemistry Letters. 2017-08, 27 (15): 3370–3373 [2021-01-26]. doi:10.1016/j.bmcl.2017.06.004. （原始内容存档于2020-02-27）（英语）.
^ E. A. Ivleva, M. R. Baimuratov, M. R. Demidov, A. V. Lukashenko, Yu. A. Malinovskaya, Yu. N. Klimochkin, V. A. Tyshchenko, I. A. Kulikova, V. V. Pozdnyakov, K. A. Ovchinnikov, K. B. Rudyak. Synthesis, Physicochemical Properties, and Thermo-Oxidative Stability of Diesters of 5,7-Dimethyl-1,3-Adamantanediol and 5,7-Dimethyl-1,3-bis(Hydroxymethyl)adamantane. Petroleum Chemistry. 2018-08, 58 (8): 687–693 [2021-01-26]. ISSN 0965-5441. doi:10.1134/S096554411808008X （英语）.
^ Hiyoshizo Kotsuki, Yasuyuki Ushio, Naka Yoshimura, Masamitsu Ochi. Efficient Reduction of Acyl Chlorides with Zn(BH 4 ) 2 / N , N , N ′, N ′-Tetramethylethylenediamine. Bulletin of the Chemical Society of Japan. 1988-07, 61 (7): 2684–2686 [2021-01-26]. ISSN 0009-2673. doi:10.1246/bcsj.61.2684 （英语）.
^ Ali Md. Ahad, Song Zuohe, Lei Du-Cuny, Sylvestor A. Moses, Li Li Zhou, Shuxing Zhang, Garth Powis, Emmanuelle J. Meuillet, Eugene A. Mash. Development of sulfonamide AKT PH domain inhibitors. Bioorganic & Medicinal Chemistry. 2011-03, 19 (6): 2046–2054 [2021-01-26]. doi:10.1016/j.bmc.2011.01.049. （原始内容存档于2020-02-15）（英语）.

[1] Calculated using Advanced Chemistry Development (ACD/Labs) Software V11.02 ((C) 1994-2021 ACD/Labs). Retrieved from SciFinderⁿ. [2021-01-26].

[2] "PhysProp" data were obtained from Syracuse Research Corporation of Syracuse, New York (US). Retrieved from SciFinderⁿ. [2021-01-26].

[3] Toriyama, Masaharu; Kamijo, Haruo; Motohashi, Shigeyasu; Takido, Toshio; Itabashi, Kunio. A Facile Synthesis of Thioacids by Hydrolysis of 1-(Acylthio)ethaniminium Chlorides. Phosphorus, Sulfur, and Silicon and the Related Elements. 2010, 178 (8): 1661–1665. ISSN 1042-6507. doi:10.1080/10426500307837.

[4] Cainelli, Gianfranco; Contento, Michele; Manescalchi, Francesco; Plessi, Laura. Polymer-Bonded Lewis Acids in Organic Synthesis: Conversion of Carboxylic Acids into Acyl Chlorides and of Alcohols into Alkyl Chlorides or Bromides by Polymer-Bonded Phosphorus Reagents. Synthesis. 1983, 1983 (04): 306–308. ISSN 0039-7881. doi:10.1055/s-1983-30314.

[5] Srikanth Vudhgiri, Dhevendar Koude, Dileep Kumar Veeragoni, Sunil Misra, R.B.N. Prasad, Ram Chandra Reddy Jala. Synthesis and biological evaluation of 5-fatty-acylamido-1, 3, 4-thiadiazole-2-thioglycosides. Bioorganic & Medicinal Chemistry Letters. 2017-08, 27 (15): 3370–3373 [2021-01-26]. doi:10.1016/j.bmcl.2017.06.004. （原始内容存档于2020-02-27）（英语）.

[6] E. A. Ivleva, M. R. Baimuratov, M. R. Demidov, A. V. Lukashenko, Yu. A. Malinovskaya, Yu. N. Klimochkin, V. A. Tyshchenko, I. A. Kulikova, V. V. Pozdnyakov, K. A. Ovchinnikov, K. B. Rudyak. Synthesis, Physicochemical Properties, and Thermo-Oxidative Stability of Diesters of 5,7-Dimethyl-1,3-Adamantanediol and 5,7-Dimethyl-1,3-bis(Hydroxymethyl)adamantane. Petroleum Chemistry. 2018-08, 58 (8): 687–693 [2021-01-26]. ISSN 0965-5441. doi:10.1134/S096554411808008X （英语）.

[7] Hiyoshizo Kotsuki, Yasuyuki Ushio, Naka Yoshimura, Masamitsu Ochi. Efficient Reduction of Acyl Chlorides with Zn(BH 4 ) 2 / N , N , N ′, N ′-Tetramethylethylenediamine. Bulletin of the Chemical Society of Japan. 1988-07, 61 (7): 2684–2686 [2021-01-26]. ISSN 0009-2673. doi:10.1246/bcsj.61.2684 （英语）.

[8] Ali Md. Ahad, Song Zuohe, Lei Du-Cuny, Sylvestor A. Moses, Li Li Zhou, Shuxing Zhang, Garth Powis, Emmanuelle J. Meuillet, Eugene A. Mash. Development of sulfonamide AKT PH domain inhibitors. Bioorganic & Medicinal Chemistry. 2011-03, 19 (6): 2046–2054 [2021-01-26]. doi:10.1016/j.bmc.2011.01.049. （原始内容存档于2020-02-15）（英语）.

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