CD43

CD43
識別號
別名	SPN；, CD43, GALGP, GPL115, LSN, sialophorin, LEU-22
外部ID	OMIM：182160 MGI：98384 HomoloGene：36108 GeneCards：SPN
基因位置（人類）
染色體	16號染色體
終止	29,670,876 bp
基因位置（小鼠）
染色體	小鼠7號染色體
終止	126,736,995 bp
基因本體
分子功能	• transmembrane signaling receptor activity; • Hsp70 protein binding; • heat shock protein binding;
細胞組分	• integral component of membrane; • 膜; • 細胞膜; • integral component of plasma membrane; • 基底膜; • cell surface; • 尾肢; • 外排體; • external side of plasma membrane; • 細胞外空間;
生物學過程	• negative regulation of cell adhesion; • positive regulation of protein phosphorylation; • negative regulation of type IV hypersensitivity; • response to protozoan; • T cell costimulation; • negative thymic T cell selection; • 趨化性; • establishment or maintenance of cell polarity; • cellular defense response; • cell surface receptor signaling pathway; • negative regulation of T cell proliferation; • defense response to bacterium; • 免疫反應; • positive regulation of T cell proliferation; • regulation of immune response; • apoptotic signaling pathway; • regulation of defense response to virus; • negative regulation of T cell activation; • leukocyte migration; • 訊息傳遞;
	Sources:Amigo / QuickGO
直系同源
	6693
	20737
	ENSG00000197471
	ENSMUSG00000051457
	P16150
	P15702
	NM_001030288; NM_003123
	NM_001037810; NM_009259
	NP_001025459; NP_003114
	NP_001032899; NP_033285
	維基數據
檢視/編輯人類	檢視/編輯小鼠

CD43（白細胞分化抗原43）又名白細胞唾液酸糖蛋白（Leukosialin）或唾液酸蛋白（sialophorin），是一種跨膜表面蛋白，在人體中由SPN（唾液蛋白）基因編碼^[5]^[6]^[7]。

功能[編輯]

唾液蛋白（leukosialin）是人類T淋巴細胞，單核細胞，粒細胞和一些B淋巴細胞表面的主要唾液酸糖蛋白，它們似乎對免疫功能很重要，可能是參與T細胞活化的生理性配體 - 受體複合物的一部分^[6]。

臨床意義[編輯]

CD43分子中的缺陷與Wiskott-Aldrich綜合徵的發病有關^[8]。也在大約25％的腸道MALT瘤中出現，通過免疫組織化學技術，可以在健康淋巴結和扁桃體的皮質T細胞中證實CD43的存在。CD43在一系列淋巴和骨髓腫瘤中也是陽性的。雖然它於超過90％的T細胞淋巴瘤中存在，但它在診斷這些病症方面通常不如CD3抗原有效。然而，它可以作為一系列抗原的一部分用於診斷B細胞淋巴母細胞淋巴瘤，因為在這種情況下的惡性細胞通常CD43是陽性的，並且可能難以用其他抗體染色。因為它會污染粒細胞及其前體細胞，它也是骨髓瘤的有效標記物^[9]。

相互作用[編輯]

CD43已被證實與埃茲蛋白Ezrin^[10]和膜突蛋白Moesin^[11]具有相互作用。

參考文獻[編輯]

^ ^1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000197471 - Ensembl, May 2017
^ ^2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000051457 - Ensembl, May 2017
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ SPN sialophorin [Homo sapiens (human)] - Gene - NCBI. www.ncbi.nlm.nih.gov. [2018-07-15]. （原始內容存檔於2019-02-15）.
^ ^6.0 ^6.1 Pallant, A.; Eskenazi, A.; Mattei, M. G.; Fournier, R. E.; Carlsson, S. R.; Fukuda, M.; Frelinger, J. G. Characterization of cDNAs encoding human leukosialin and localization of the leukosialin gene to chromosome 16. Proceedings of the National Academy of Sciences of the United States of America. 1989-2, 86 (4): 1328–1332 [2018-07-15]. ISSN 0027-8424. PMC 286683 . PMID 2521952. （原始內容存檔於2018-08-20）. 請檢查|date=中的日期值 (幫助)
^ Shelley, C. S.; Remold-O'Donnell, E.; Davis, A. E.; Bruns, G. A.; Rosen, F. S.; Carroll, M. C.; Whitehead, A. S. Molecular characterization of sialophorin (CD43), the lymphocyte surface sialoglycoprotein defective in Wiskott-Aldrich syndrome. Proceedings of the National Academy of Sciences of the United States of America. 1989-4, 86 (8): 2819–2823 [2018-07-15]. ISSN 0027-8424. PMC 287010 . PMID 2784859. （原始內容存檔於2018-08-20）. 請檢查|date=中的日期值 (幫助)
^ Remold-O'Donnell, E.; Rosen, F. S. Sialophorin (CD43) and the Wiskott-Aldrich syndrome. Immunodeficiency Reviews. 1990, 2 (2): 151–174 [2018-07-15]. ISSN 0893-5300. PMID 2223062. （原始內容存檔於2018-07-16）.
^ 1945-2011., Leong, Anthony S.-Y. (Anthony Siew-Yin),; W.-M., Leong, F. Joel. Manual of diagnostic antibodies for immunohistology. 2nd ed. London: Greenwich Medical Media https://www.worldcat.org/oclc/51439459. 2003 [2018-07-15]. ISBN 9781841101002. OCLC 51439459. （原始內容存檔於2019-09-24）. 缺少或|title=為空 (幫助)
^ Serrador, J. M.; Nieto, M.; Alonso-Lebrero, J. L.; del Pozo, M. A.; Calvo, J.; Furthmayr, H.; Schwartz-Albiez, R.; Lozano, F.; González-Amaro, R. CD43 interacts with moesin and ezrin and regulates its redistribution to the uropods of T lymphocytes at the cell-cell contacts. Blood. 1998-06-15, 91 (12): 4632–4644 [2018-07-15]. ISSN 0006-4971. PMID 9616160. （原始內容存檔於2018-07-15）.
^ Yonemura, S.; Hirao, M.; Doi, Y.; Takahashi, N.; Kondo, T.; Tsukita, S.; Tsukita, S. Ezrin/radixin/moesin (ERM) proteins bind to a positively charged amino acid cluster in the juxta-membrane cytoplasmic domain of CD44, CD43, and ICAM-2. The Journal of Cell Biology. 1998-02-23, 140 (4): 885–895 [2018-07-15]. ISSN 0021-9525. PMC 2141743 . PMID 9472040. （原始內容存檔於2018-07-16）.

外部連結[編輯]

醫學主題詞表（MeSH）：CD43+antigen
Human SPN genome location and SPN gene details page in the UCSC Genome Browser（英語：UCSC Genome Browser）.

[refGRCh38Ensembl-1] 1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000197471 - Ensembl, May 2017

[refGRCm38Ensembl-2] 2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000051457 - Ensembl, May 2017

[3] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] SPN sialophorin [Homo sapiens (human)] - Gene - NCBI. www.ncbi.nlm.nih.gov. [2018-07-15]. （原始內容存檔於2019-02-15）.

[:0-6] 6.0 ^6.1 Pallant, A.; Eskenazi, A.; Mattei, M. G.; Fournier, R. E.; Carlsson, S. R.; Fukuda, M.; Frelinger, J. G. Characterization of cDNAs encoding human leukosialin and localization of the leukosialin gene to chromosome 16. Proceedings of the National Academy of Sciences of the United States of America. 1989-2, 86 (4): 1328–1332 [2018-07-15]. ISSN 0027-8424. PMC 286683 . PMID 2521952. （原始內容存檔於2018-08-20）. 請檢查|date=中的日期值 (幫助)

[7] Shelley, C. S.; Remold-O'Donnell, E.; Davis, A. E.; Bruns, G. A.; Rosen, F. S.; Carroll, M. C.; Whitehead, A. S. Molecular characterization of sialophorin (CD43), the lymphocyte surface sialoglycoprotein defective in Wiskott-Aldrich syndrome. Proceedings of the National Academy of Sciences of the United States of America. 1989-4, 86 (8): 2819–2823 [2018-07-15]. ISSN 0027-8424. PMC 287010 . PMID 2784859. （原始內容存檔於2018-08-20）. 請檢查|date=中的日期值 (幫助)

[8] Remold-O'Donnell, E.; Rosen, F. S. Sialophorin (CD43) and the Wiskott-Aldrich syndrome. Immunodeficiency Reviews. 1990, 2 (2): 151–174 [2018-07-15]. ISSN 0893-5300. PMID 2223062. （原始內容存檔於2018-07-16）.

[9] 1945-2011., Leong, Anthony S.-Y. (Anthony Siew-Yin),; W.-M., Leong, F. Joel. Manual of diagnostic antibodies for immunohistology. 2nd ed. London: Greenwich Medical Media https://www.worldcat.org/oclc/51439459. 2003 [2018-07-15]. ISBN 9781841101002. OCLC 51439459. （原始內容存檔於2019-09-24）. 缺少或|title=為空 (幫助)

[10] Serrador, J. M.; Nieto, M.; Alonso-Lebrero, J. L.; del Pozo, M. A.; Calvo, J.; Furthmayr, H.; Schwartz-Albiez, R.; Lozano, F.; González-Amaro, R. CD43 interacts with moesin and ezrin and regulates its redistribution to the uropods of T lymphocytes at the cell-cell contacts. Blood. 1998-06-15, 91 (12): 4632–4644 [2018-07-15]. ISSN 0006-4971. PMID 9616160. （原始內容存檔於2018-07-15）.

[11] Yonemura, S.; Hirao, M.; Doi, Y.; Takahashi, N.; Kondo, T.; Tsukita, S.; Tsukita, S. Ezrin/radixin/moesin (ERM) proteins bind to a positively charged amino acid cluster in the juxta-membrane cytoplasmic domain of CD44, CD43, and ICAM-2. The Journal of Cell Biology. 1998-02-23, 140 (4): 885–895 [2018-07-15]. ISSN 0021-9525. PMC 2141743 . PMID 9472040. （原始內容存檔於2018-07-16）.

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